Percentage of bleeding on probing (BOP) · Adults (any age/sex) with chronic periodontitis (>=5 teeth remaining; PPD >4 mm), with or without hypertension
Intensive periodontal treatment (subgingival SRP with or without… led to lower bleeding on probing (BOP) compared with supra-gingival scaling; GRADE not reported.
2 findings from 1 review
Number of cases of dementia Range of · participants without prior cerebrovascular disease for prevention of cognitive impairment and dementia
It is very uncertain whether antihypertensive therapy changes number of cases of dementia Range of compared with placebo (very low certainty).
1 finding from 1 review
Change in MMSE · participants without prior cerebrovascular disease for prevention of cognitive impairment and dementia
1 finding from 1 review
Systolic blood pressure (mmHg), change from baseline · participants without prior cerebrovascular disease for prevention of cognitive impairment and dementia
1 finding from 1 review
Diastolic blood pressure (mmHg), change from baseline · participants without prior cerebrovascular disease for prevention of cognitive impairment and dementia
1 finding from 1 review
Adverse effects Range of · participants without prior cerebrovascular disease for prevention of cognitive impairment and dementia
1 finding from 1 review
Quality of life measured via Sickness Impact Profile, PGWB Positive well‐being, and EuroQoL Current Health Range of · participants without prior cerebrovascular disease for prevention of cognitive impairment and dementia
1 finding from 1 review
Change in Mutans streptococci (MS) count in saliva · healthy people
Xylitol and sorbitol did not differ significantly for Mutans streptococci in saliva (SMD -0.16, 95% CI -0.44 to 0.12; 2 trials, P=.25); not GRADE-rated.
1 finding from 1 review
Change in Mutans streptococci (MS) count in dental plaque · healthy people
Xylitol reduced Mutans streptococci in dental plaque more than sorbitol (SMD -0.45, 95% CI -0.69 to -0.21; 4 trials, I2=7%); not GRADE-rated.
1 finding from 1 review
Service use: 1. Average number of days in hospital per month ‐ by about 24 months · people with severe mental disorders
1 finding from 1 review
Adverse event: 1b. Death ‐ suicide ‐ by long term · people with severe mental disorders
Intensive Case Management showed no clear difference in adverse event: 1b. Death ‐ suicide ‐ by long term compared with standard care (low certainty).
1 finding from 1 review
Relapse · people with severe mental disorders
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Leaving the study early · people with severe mental disorders
Intensive Case Management may leads to lower global state: 1. Leaving the study early ‐ by long term compared with standard care (low certainty).
1 finding from 1 review
Social functioning: 2. Employment status (various measurements) ‐ by long term ‐ not employed at the end of the trial · people with severe mental disorders
It is very uncertain whether intensive Case Management changes social functioning: 2. Employment status (various measurements) ‐ by… compared with standard care (very low certainty).
1 finding from 1 review
Mental state: No clinically important improvement · people with severe mental disorders
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Macrovascular complications · persons with type 1 diabetes mellitus
1 finding from 1 review
no estimate extracted
Studies not reported
Low
Adverse events · persons with type 1 diabetes mellitus
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Severe hypoglycaemia, baseline HbA1c < 9.0 · persons with type 1 diabetes mellitus
Intensive glucose control may leads to higher severe hypoglycaemia, baseline HbA1c < 9.0 compared with conventional glucose control (low certainty).
1 finding from 1 review
Severe hypoglycaemia, baseline HbA1c ≥9.0 · persons with type 1 diabetes mellitus
Intensive glucose control showed no clear difference in severe hypoglycaemia, baseline HbA1c ≥9.0 compared with conventional glucose control (low certainty).
1 finding from 1 review
Ketoacidosis · persons with type 1 diabetes mellitus
It is very uncertain whether intensive glucose control changes ketoacidosis compared with conventional glucose control (very low certainty).
1 finding from 1 review