Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

392 questions · 405 findings · 52 reviews

No studies found 96 · 23.7%GRADE not reported 57 · 14.1%Very low 64 · 15.8%Low 77 · 19%Moderate 63 · 15.6%High 48 · 11.9%

Mammography in combination with breast ultrasonography vs mammography alone

Rate of biopsies · s of women with dense and non‐dense breasts

Mammography in combination with breast ultrasonography leads to higher rate of biopsies compared with mammography alone (high certainty).

1 finding from 1 review

Mammography in combination with breast ultrasonography vs mammography alone

Incremental cancer detection: cohort studies · s of women with dense and non‐dense breasts

Mammography in combination with breast ultrasonography leads to higher incremental cancer detection: RCT compared with mammography alone (high certainty).

2 findings from 1 review

Mammography in combination with breast ultrasonography vs mammography alone

Incremental detection of invasive cancers · s of women with dense and non‐dense breasts

Mammography in combination with breast ultrasonography showed no clear difference in incremental detection of invasive cancers: RCT compared with mammography alone (low certainty).

2 findings from 1 review

Mammography in combination with breast ultrasonography vs mammography alone

Interval cancer · s of women with dense and non‐dense breasts

Mammography in combination with breast ultrasonography leads to lower interval cancer compared with mammography alone (high certainty).

1 finding from 1 review

Mammography in combination with breast ultrasonography vs mammography alone

Lymph node status · s of women with dense and non‐dense breasts

Mammography in combination with breast ultrasonography probably leads to lower lymph node status compared with mammography alone (moderate certainty).

1 finding from 1 review

Referral to a specific dental treatment facility vs Generic advice letter to see a dentist

Dental attendance · School children, primary school in Saudi Arabia

It is very uncertain whether referral to a specific dental treatment facility changes dental attendance (number of dental visits) compared with generic advice letter to see a dentist (very low certainty).

1 finding from 1 review

Referral letter based on the common-sense model (CSM) of self-regulation vs Standard referral letter

Proportion of children with treated/untreated caries (receipt of dental care) · School children, primary schools in the USA

It is very uncertain whether referral letter based on the common-sense model (CSM) of… changes proportion of children with treated/untreated caries (receipt of… compared with standard referral letter (very low certainty).

1 finding from 1 review

Referral letter based on the common-sense model (CSM) plus dental information guide (DIG) vs Referral letter based on the common-sense model (CSM) alone

Proportion of children with treated/untreated caries (receipt of dental care) · School children, primary schools in the USA

It is very uncertain whether referral letter based on the common-sense model (CSM) plus dental… changes proportion of children with treated/untreated caries (receipt of… compared with referral letter based on the common-sense model (CSM) alone (very low certainty).

1 finding from 1 review

Referral to a specific dental treatment facility vs Generic advice letter to see a dentist

Number of caries in primary teeth (dt index) · School children, primary school in Saudi Arabia

It is very uncertain whether referral to a specific dental treatment facility changes number of caries in primary teeth (dt index) compared with generic advice letter to see a dentist (very low certainty).

1 finding from 1 review

Referral to a specific dental treatment facility vs Generic advice letter to see a dentist

Number of caries in permanent teeth (DT index) · School children, primary school in Saudi Arabia

It is very uncertain whether referral to a specific dental treatment facility changes number of caries in permanent teeth (DT index) compared with generic advice letter to see a dentist (very low certainty).

1 finding from 1 review

Referral letter based on the common-sense model (CSM) of self-regulation plus dental information guide (DIG) vs Standard referral letter

Proportion of children with treated/untreated caries (receipt of dental care) · School children, primary schools in the USA

It is very uncertain whether referral letter based on the common-sense model (CSM) of… changes proportion of children with treated/untreated caries (receipt of… compared with standard referral letter (very low certainty).

1 finding from 1 review

Intervention not reported

Index test · children with close tuberculosis contacts Index tests: groups of multiple symptoms Role: an initial test Threshold for index tests: any 1…

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Specificities 99% and 100% · children evaluated in inpatient or outpatient settings Index tests: Xpert MTB/RIF Role: an initial test Threshold for index tests: an…
1 finding from 1 review

Intervention not reported

≥ 1 of cough, fever, or poor weight gain · children with close tuberculosis contacts Index tests: groups of multiple symptoms Role: an initial test Threshold for index tests: any 1…
1 finding from 1 review

Intervention not reported

≥ 1 of cough, fever, or decreased playfulness · children with close tuberculosis contacts Index tests: groups of multiple symptoms Role: an initial test Threshold for index tests: any 1…
1 finding from 1 review

Intervention not reported

≥ 1 of cough, fever, poor weight gain, or tuberculosis close contact (WHO 4‐symptom symptom screen) · children with close tuberculosis contacts Index tests: groups of multiple symptoms Role: an initial test Threshold for index tests: any 1…
1 finding from 1 review

Intervention not reported

Estimation (95% Cl) · children with close tuberculosis contacts Index test: abnormal chest radiography Role: an initial test Threshold for index tests: author…

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Pooled sensitivity 87% (75% to 93%) · children with close tuberculosis contacts Index test: abnormal chest radiography Role: an initial test Threshold for index tests: author…
1 finding from 1 review