Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,747 questions · 3,943 findings · 594 reviews

No studies found 784 · 19.9%GRADE not reported 530 · 13.4%Very low 1,040 · 26.4%Low 981 · 24.9%Moderate 444 · 11.3%High 164 · 4.2%

Glass ionomer sealant (with fluoride gel plus dentifrice) vs Fluoride gel plus fluoride toothpaste/dentifrice (non-invasive control)

Caries (lesion) progression (radiographic) · Dentate children and adults with non-cavitated proximal caries lesions extending into enamel or dentine (not pulp) in primary or permanent…

Glass ionomer sealant (with fluoride gel plus dentifrice) showed no clear difference in caries (lesion) progression (radiographic) compared with fluoride gel plus fluoride toothpaste/dentifrice (non-invasive…; GRADE not reported.

1 finding from 1 review

Hyperbaric oxygen vs air breathing to enhance the effectiveness of radiotherapy

Failure of local tumour control ‐ not reported · People undergoing radiation therapy for head and neck cancer

Hyperbaric oxygen probably leads to lower failure of local tumour control (local control) compared with air breathing to enhance the effectiveness of radiotherapy (moderate certainty).

1 finding from 1 review

Bone morphogenetic protein-2 (BMP-2) together with platelet-rich fibrin vs Platelet-rich fibrin (PRF)

Healing of MRONJ · People with established (manifest) MRONJ

It is very uncertain whether bone morphogenetic protein-2 (BMP-2) together with platelet-rich… changes healing of MRONJ compared with platelet-rich fibrin alone (very low certainty).

1 finding from 1 review