Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,938 questions · 2,020 findings · 107 reviews

No studies found 570 · 28.2%GRADE not reported 266 · 13.2%Very low 578 · 28.6%Low 462 · 22.9%Moderate 118 · 5.8%High 26 · 1.3%

naltrexone vs no pharmacological

Criminal activity dichotomous ‐ Reincarceration official records · patients with drug‐using offenders

Summary of findings for the main comparisons: Antagonost (Naltrexone) probably leads to lower criminal activity dichotomous ‐ Reincarceration official records compared with no pharmacological (moderate certainty).

1 finding from 1 review

Occlusal splint vs Pharmacological interventions (benzodiazepines, anticonvulsants, beta blockers, dopamine agents, antidepressants, botulinum toxin A and B, analgesics)

Outcome not reported · People with sleep bruxism (tooth grinding or clenching); children (greater than 1 year old) and adults; diagnosis clinical,…

The review found no eligible studies for this question.

1 finding from 1 review

Surgery vs preoperative pharmacological therapy and surgery

Adverse events · adults with growth‐hormone secreting pituitary adenomas

It is very uncertain whether surgery alone changes adverse events compared with preoperative pharmacological therapy and surgery (very low certainty).

1 finding from 1 review

Surgery vs preoperative pharmacological therapy and surgery

Surgery for recurrent or persistent disease · adults with growth‐hormone secreting pituitary adenomas

It is very uncertain whether surgery alone changes surgery for recurrent or persistent disease compared with preoperative pharmacological therapy and surgery (very low certainty).

1 finding from 1 review

Surgery vs preoperative pharmacological therapy and surgery

Non‐surgical therapy for recurrent or persistent diseaseRadiation therapy and/or pharmacologic therapy for recurrent or persistent disease · adults with growth‐hormone secreting pituitary adenomas

It is very uncertain whether surgery alone changes non‐surgical therapy for recurrent or persistent diseaseRadiation… compared with preoperative pharmacological therapy and surgery (very low certainty).

1 finding from 1 review