Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,103 questions · 1,157 findings · 177 reviews · Headline outcomes only

No studies found 291 · 25.2%GRADE not reported 85 · 7.3%Very low 317 · 27.4%Low 258 · 22.3%Moderate 169 · 14.6%High 37 · 3.2%

Bortezomib vs no bortezomib

Thrombocytopenia · All patients with a diagnosis of multiple myeloma

Bortezomib may leads to higher adverse Events: Thrombocytopenia compared with no bortezomib (low certainty).

3 findings from 1 review

Intervention not reported

Peritoneal lavage vs. open necrosectomy · people with necrotising pancreatitis

It is very uncertain whether the intervention changes peritoneal lavage vs. open necrosectomy (very low certainty).

1 finding from 1 review

Intervention not reported

Minimally invasive step‐up approach vs. open necrosectomy · people with necrotising pancreatitis

The intervention may leads to lower minimally invasive step‐up approach vs. open necrosectomy (low certainty).

1 finding from 1 review

Intervention not reported

Peritoneal lavage vs. open necrosectomy · people with necrotising pancreatitis

It is very uncertain whether the intervention changes peritoneal lavage vs. open necrosectomy (very low certainty).

1 finding from 1 review

Intervention not reported

Minimally invasive step‐up approach vs. open necrosectomy · people with necrotising pancreatitis

It is very uncertain whether the intervention changes minimally invasive step‐up approach vs. open necrosectomy (very low certainty).

1 finding from 1 review

Intervention not reported

Delayed open necrosectomy vs. early open necrosectomy · people with necrotising pancreatitis

It is very uncertain whether the intervention changes delayed open necrosectomy vs. early open necrosectomy (very low certainty).

1 finding from 1 review

Intervention not reported

Minimally invasive step‐up approach vs. open necrosectomy · people with necrotising pancreatitis

It is very uncertain whether the intervention changes minimally invasive step‐up approach vs. open necrosectomy (very low certainty).

1 finding from 1 review

Intervention not reported

Peritoneal lavage vs. open necrosectomy · people with necrotising pancreatitis

It is very uncertain whether the intervention changes peritoneal lavage vs. open necrosectomy (very low certainty).

1 finding from 1 review

Intervention not reported

Open surgical drainage versus EUS‐guided drainage · patients with pancreatic pseudocysts

It is very uncertain whether the intervention changes open surgical drainage versus EUS‐guided drainage (very low certainty).

1 finding from 1 review

Intervention not reported

Open surgical drainage versus EUS‐guided drainage · patients with pancreatic pseudocysts
1 finding from 1 review

Intervention not reported

Open surgical drainage versus EUS‐guided drainage Scale from: 0 to 100. Higher indicates better · patients with pancreatic pseudocysts
1 finding from 1 review

Ruxolitinib vs best available therapy

Safety (AE, adverse drug reaction): thrombocytopenia Grades 3 or 4 according to National Cancer Institute · Patients with treating MF

Ruxolitinib showed no clear difference in safety (AE, adverse drug reaction): thrombocytopenia Grades 3 or 4… compared with best available therapy (low certainty).

1 finding from 1 review

Ruxolitinib vs placebo

Safety (AE, adverse drug reaction): thrombocytopenia Grades 3 or 4 according to National Cancer Institute · Patients with treating MF

Ruxolitinib may leads to higher safety (AE, adverse drug reaction): thrombocytopenia Grades 3 or 4… compared with placebo (low certainty).

1 finding from 1 review

Non‐platinum therapies vs platinum combination

Grade 3 or higher hematological toxicity for platinum therapies ‐ thrombocytopenia · non‐small cell lung cancer in the elderly population

Non‐platinum therapies may leads to higher grade 3 or higher hematological toxicity for platinum therapies ‐… compared with platinum combination (low certainty).

1 finding from 1 review