Cochrane · systematic review · CD011322
Luteinising hormone releasing hormone (LHRH) agonists for the treatment of relapsed epithelial ovarian cancer
Wuntakal, R, Seshadri, S, Montes, A, et al. · Cochrane Database of Systematic Reviews · 2016 · Cochrane Library
Gynaecological, Neuro-oncology and Orphan CancerAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 7 · 100%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Leuprorelin compared with treosulfan for relapsed epithelial ovarian cancer
Population: Platinum‐resistant and refractory (relapsed) epithelial ovarian cancer
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Progression‐free survival at 6 months№ of participants: 73(1 RCT) Leuprorelin vs treosulfan | RR 0.61 [0.22, 1.68] | NR | Very low Downgraded: risk of bias, imprecision |
Progression‐free survival at 12 months№ of participants: 73(1 RCT) Leuprorelin vs treosulfan | RR 0.65 [0.12, 3.66] | NR | Very low Downgraded: risk of bias, imprecision |
Overall survival Leuprorelin vs treosulfan | HR 0.98 [0.58, 1.67] | NR | Very low Downgraded: risk of bias, imprecision |
Skin toxicity (alopecia)№ of participants: 73(1 RCT) Leuprorelin vs treosulfan | RR 0.32 [0.12, 0.91] | NR | Very low Downgraded: risk of bias |
Gastrointestinal toxicity (nausea and vomiting)№ of participants: 73(1 RCT) Leuprorelin vs treosulfan | RR 0.65 [0.12, 3.66] | NR | Very low Downgraded: risk of bias, imprecision |
Neurotoxicity№ of participants: 73(1 RCT) Leuprorelin vs treosulfan | RR 0.32 [0.01, 7.71] | NR | Very low Downgraded: risk of bias, imprecision |
Neutropenia grade 3/4№ of participants: 73(1 RCT) Leuprorelin vs treosulfan | no estimate extracted | NR | Very low Downgraded: risk of bias, imprecision |