Intervention not reported
"Moderate" benefit At least 30% reduction in pain · adults with peripheral neuropathic pain conditions
1 finding from 1 review
- no estimate extracted1 study · 58 participantsVery low
Findings
What do systematic reviews say?
1,304 questions · 1,352 findings · 210 reviews
No studies found 230 · 17%GRADE not reported 163 · 12.1%Very low 269 · 19.9%Low 277 · 20.5%Moderate 291 · 21.5%High 122 · 9%
Intervention not reported
Patient Global Impression of Change much or very much improved (PGPR "complete", "a lot", or "moderate") · adults with neuropathic pain (3 studies in painful diabetic neuropathy and postherpetic neuralgia)
1 finding from 1 review
- no estimate extracted2 studies · 50 participantsVery low
2 mm titanium plates vs 2.5 mm bioresorbable plates
Moderate soft tissue deformity · Adults (16 to 68 years) with mandibular fractures excluding condylar involvement
2 mm titanium plates showed no clear difference in moderate soft tissue deformity compared with 2.5 mm bioresorbable plates; GRADE not reported.
1 finding from 1 review
- RR 6.4 [0.80, 51.3]1 study · 57 participantsGRADE not reported
Intervention not reported
Moderate dose SSRI versus placebo Luteal or continuous administration · women with premenstrual syndrome
1 finding from 1 review
- Selective serotonin reuptake inhibitors for premenstrual syndrome 2013 · Cochrane Headline outcomes onlyno estimate extracted9 studies · 1276 participantsLow
Intervention not reported
Moderate dose SSRI versus placebo Luteal administration · women with premenstrual syndrome
1 finding from 1 review
- Selective serotonin reuptake inhibitors for premenstrual syndrome 2013 · Cochrane Headline outcomes onlyno estimate extracted4 studies · 457 participantsModerate
Intervention not reported
Moderate dose SSRI versus placebo Continuous administration · women with premenstrual syndrome
1 finding from 1 review
- Selective serotonin reuptake inhibitors for premenstrual syndrome 2013 · Cochrane Headline outcomes onlyno estimate extracted7 studies · 843 participantsLow
Intervention not reported
Moderate dose SSRI versus placebo Luteal administration2 · women with premenstrual syndrome
1 finding from 1 review
- Selective serotonin reuptake inhibitors for premenstrual syndrome 2013 · Cochrane Headline outcomes onlyno estimate extracted4 studies · 657 participantsModerate
Strong opioids vs placebo
At least 30% reduction in pain · adults with chronic low‐back pain
Strong opioids probably leads to higher at least 30% of pain relief or moderate relief compared with placebo (moderate certainty).
1 finding from 1 review
- Opioids compared to placebo or other treatments for chronic low‐back pain 2013 · Cochrane Headline outcomes onlyOR 1.91 [1.41, 2.58]3 studies · 819 participantsModerate
Topiramate 200 to 400 mg vs placebo
Participant‐reported pain relief of 30% or greater · neuropathic pain (two studies found in painful diabetic neuropathy, and one in lumbar radiculopathy)
1 finding from 1 review
- no estimate extracted1 study · 317 participantsGRADE not reported
Long‐acting beta2‐agonists vs placebo
Moderate exacerbations (course of antibiotics or oral steroids) · patients with chronic obstructive pulmonary disease
Long‐acting beta2‐agonists probably leads to lower moderate exacerbations (course of antibiotics or oral steroids) compared with placebo (moderate certainty).
1 finding from 1 review
- Long‐acting beta₂‐agonists for chronic obstructive pulmonary disease 2013 · Cochrane Headline outcomes onlyOR 0.73 [0.61, 0.87]7 studies · 3375 participantsModerate
Long‐acting beta2‐agonists vs placebo
Moderate‐to‐severe exacerbations (rate) · patients with chronic obstructive pulmonary disease
Long‐acting beta2‐agonists showed no clear difference in severe/moderate exacerbations (hospitalisation or course of… compared with placebo (moderate certainty).
1 finding from 1 review
- Long‐acting beta₂‐agonists for chronic obstructive pulmonary disease 2013 · Cochrane Headline outcomes onlyOR 0.88 [0.76, 1.02]7 studies · 3968 participantsModerate
Sodium hypochlorite (NaOCl), 2.5% to 5.25% vs Sodium hypochlorite 1%
Proportion of participants with moderate to severe pain 72 hours to 14 days after the procedure · Patients aged 14 to 78 years with mature permanent teeth (fully formed roots), single or multi-rooted, with pulpal or periapical…
The review found no eligible studies for this question.
1 finding from 1 review
- Irrigants for non‐surgical root canal treatment in mature permanent teeth 2012 · Cochrane All outcomesno estimate extracted0 studiesNo studies found
Sodium hypochlorite 5.25% vs Normal saline
Proportion of participants with moderate to severe pain 72 hours to 14 days after the procedure · Patients aged 14 to 78 years with mature permanent teeth (fully formed roots), single or multi-rooted, with pulpal or periapical…
Sodium hypochlorite 5.25% showed no clear difference in proportion of participants with moderate to severe pain 72 hours to… compared with normal saline; GRADE not reported.
1 finding from 1 review
- Irrigants for non‐surgical root canal treatment in mature permanent teeth 2012 · Cochrane All outcomesRR 0.8 [0.27, 2.5]1 study · 178 participantsGRADE not reported
Sodium hypochlorite 1.3% with MTAD final rinse vs Sodium hypochlorite 1.3% with normal saline final rinse
Proportion of participants with moderate to severe pain up to 6 hours after the procedure · Patients aged 14 to 78 years with mature permanent teeth (fully formed roots), single or multi-rooted, with pulpal or periapical…
The review found no eligible studies for this question.
1 finding from 1 review
- Irrigants for non‐surgical root canal treatment in mature permanent teeth 2012 · Cochrane All outcomesno estimate extracted0 studiesNo studies found
Chlorhexidine 0.2% vs Normal saline
Proportion of participants with moderate to severe pain 72 hours to 14 days after the procedure · Patients aged 14 to 78 years with mature permanent teeth (fully formed roots), single or multi-rooted, with pulpal or periapical…
The review found no eligible studies for this question.
1 finding from 1 review
- Irrigants for non‐surgical root canal treatment in mature permanent teeth 2012 · Cochrane All outcomesno estimate extracted0 studiesNo studies found
Sodium hypochlorite 5% vs Sodium hypochlorite 5% with proteolytic enzyme
Proportion of participants with moderate to severe pain 72 hours to 14 days after the procedure · Patients aged 14 to 78 years with mature permanent teeth (fully formed roots), single or multi-rooted, with pulpal or periapical…
1 finding from 1 review
- Irrigants for non‐surgical root canal treatment in mature permanent teeth 2012 · Cochrane All outcomesNone of the participants in either intervention group reported moderate to severe pain persisting after day 2.1 study · 166 participantsGRADE not reported
Sodium hypochlorite (NaOCl), 2.5% to 5.25% vs Chlorhexidine, 0.2% to 2% (solution or gel)
Proportion of participants with moderate to severe pain up to 6 hours after the procedure · Patients aged 14 to 78 years with mature permanent teeth (fully formed roots), single or multi-rooted, with pulpal or periapical…
The review found no eligible studies for this question.
1 finding from 1 review
- Irrigants for non‐surgical root canal treatment in mature permanent teeth 2012 · Cochrane All outcomesno estimate extracted0 studiesNo studies found
Sodium hypochlorite 5.25% vs Normal saline
Proportion of participants with moderate to severe pain up to 6 hours after the procedure · Patients aged 14 to 78 years with mature permanent teeth (fully formed roots), single or multi-rooted, with pulpal or periapical…
The review found no eligible studies for this question.
1 finding from 1 review
- Irrigants for non‐surgical root canal treatment in mature permanent teeth 2012 · Cochrane All outcomesno estimate extracted0 studiesNo studies found
Sodium hypochlorite 5% vs Sodium hypochlorite 5% with proteolytic enzyme
Proportion of participants with moderate to severe pain up to 6 hours after the procedure · Patients aged 14 to 78 years with mature permanent teeth (fully formed roots), single or multi-rooted, with pulpal or periapical…
Sodium hypochlorite 5% showed no clear difference in proportion of participants with moderate to severe pain up to 6… compared with sodium hypochlorite 5% with proteolytic enzyme; GRADE not reported.
1 finding from 1 review
- Irrigants for non‐surgical root canal treatment in mature permanent teeth 2012 · Cochrane All outcomesRR 1.5 [0.4, 5.0]1 study · 166 participantsGRADE not reported
Sodium hypochlorite 5.25% vs Sodium hypochlorite 5.25% with hydrogen peroxide 3%
Proportion of participants with moderate to severe pain up to 6 hours after the procedure · Patients aged 14 to 78 years with mature permanent teeth (fully formed roots), single or multi-rooted, with pulpal or periapical…
The review found no eligible studies for this question.
1 finding from 1 review
- Irrigants for non‐surgical root canal treatment in mature permanent teeth 2012 · Cochrane All outcomesno estimate extracted0 studiesNo studies found