Findings

What do systematic reviews say?

748 questions · 782 findings · 58 reviews · Gynaecological, Neuro-oncology and Orphan Cancer

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No studies found 164 · 21%GRADE not reported 26 · 3.3%Very low 151 · 19.3%Low 222 · 28.4%Moderate 158 · 20.2%High 61 · 7.8%

Intervention not reported

Chemotherapy toxicity · Adults with recurrent GBM

1 finding from 1 review

Procarbazine, lomustine and vincristine for recurrent high‐grade glioma 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 35 participants
Very low

Intervention not reported

Chemotherapy toxicity During 1st 12 weeks of treatment · Adults with recurrent HGG

1 finding from 1 review

Procarbazine, lomustine and vincristine for recurrent high‐grade glioma 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 441 participants
Moderate

Intervention not reported

Photodynamic therapy versus laser vaporisationand surgical excision · women with usual‐type vulval intraepithelial neoplasia

1 finding from 1 review

Medical and surgical interventions for the treatment of usual‐type vulval intraepithelial neoplasia 2016 · Cochrane Headline outcomes only
no estimate extracted
1 study · 52 participants
Very low

Exercise vs no exercise

Fatigue · adults with breast or prostate cancer receiving radiation therapy alone

1 finding from 1 review

Exercise interventions for adults with cancer receiving radiation therapy alone 2023 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 112 participants
Low

Exercise vs no exercise

QoL · adults with breast or prostate cancer receiving radiation therapy alone

1 finding from 1 review

Exercise interventions for adults with cancer receiving radiation therapy alone 2023 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 112 participants
Low

Exercise vs no exercise

Physical performance · adults with breast or prostate cancer receiving radiation therapy alone

1 finding from 1 review

Exercise interventions for adults with cancer receiving radiation therapy alone 2023 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 112 participants
Very low

Exercise vs no exercise

Psychosocial effects Measured at 5‐8 weeks (short term); end scores. Positive SMD values signify better psychosocial effects. · adults with breast or prostate cancer receiving radiation therapy alone

1 finding from 1 review

Exercise interventions for adults with cancer receiving radiation therapy alone 2023 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 58 participants
Very low

Exercise vs no exercise

Overall survival · adults with breast or prostate cancer receiving radiation therapy alone

The review found no eligible studies for this question.

1 finding from 1 review

Exercise interventions for adults with cancer receiving radiation therapy alone 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Exercise vs no exercise

Return to work · adults with breast or prostate cancer receiving radiation therapy alone

The review found no eligible studies for this question.

1 finding from 1 review

Exercise interventions for adults with cancer receiving radiation therapy alone 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Exercise vs no exercise

Adverse events · adults with breast or prostate cancer receiving radiation therapy alone

1 finding from 1 review

Exercise interventions for adults with cancer receiving radiation therapy alone 2023 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 45 participants
Very low

Hyperbaric oxygen vs air breathing

Metastasis · People undergoing radiotherapy for uterine cervical cancer

Hyperbaric oxygen showed no clear difference in metastasis compared with air breathing (high certainty).

1 finding from 1 review

Hyperbaric oxygenation for tumour sensitisation to radiotherapy 2018 · Cochrane Headline outcomes only
RR 1.05 [0.84, 1.31]
3 studies · 520 participants
High

Hyperbaric oxygen vs air breathing

Quality of life ‐ not reported · People undergoing radiotherapy for uterine cervical cancer

The review found no eligible studies for this question.

1 finding from 1 review

Hyperbaric oxygenation for tumour sensitisation to radiotherapy 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Hyperbaric oxygen vs air breathing

Adverse effects · People undergoing radiotherapy for uterine cervical cancer

Hyperbaric oxygen leads to higher adverse effects compared with air breathing (high certainty).

1 finding from 1 review

Hyperbaric oxygenation for tumour sensitisation to radiotherapy 2018 · Cochrane Headline outcomes only
RR 2.05 [1.22, 3.46]
3 studies · 456 participants
High

Hyperbaric oxygen vs air breathing

All‐cause mortality · People undergoing radiotherapy for uterine cervical cancer

Hyperbaric oxygen showed no clear difference in mortality compared with air breathing (high certainty).

1 finding from 1 review

Hyperbaric oxygenation for tumour sensitisation to radiotherapy 2018 · Cochrane Headline outcomes only
RR 0.88 [0.69, 1.11]
4 studies · 728 participants
High

Hyperbaric oxygen vs air breathing

Failure of local tumour control ‐ not reported · People undergoing radiotherapy for uterine cervical cancer

The review found no eligible studies for this question.

1 finding from 1 review

Hyperbaric oxygenation for tumour sensitisation to radiotherapy 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Hyperbaric oxygen vs air breathing

Local recurrence · People undergoing radiotherapy for uterine cervical cancer

Hyperbaric oxygen showed no clear difference in local recurrence (recurrence) compared with air breathing (high certainty).

1 finding from 1 review

Hyperbaric oxygenation for tumour sensitisation to radiotherapy 2018 · Cochrane Headline outcomes only
RR 0.82 [0.63, 1.06]
3 studies · 714 participants
High

Probiotics vs placebo

Diarrhoea · participants with cancer treated with radiotherapy (with or without chemotherapy)

1 finding from 1 review

Probiotics for the prevention or treatment of chemotherapy‐ or radiotherapy‐related diarrhoea in people with cancer 2018 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 771 participants
Low

Probiotics vs placebo

Diarrhoea · participants with cancer treated with chemotherapy

Probiotics may leads to lower any diarrhoea compared with placebo (low certainty).

1 finding from 1 review

Probiotics for the prevention or treatment of chemotherapy‐ or radiotherapy‐related diarrhoea in people with cancer 2018 · Cochrane Headline outcomes only
RR 0.59 [0.36, 0.96]
2 studies · 106 participants
Low

Probiotics vs placebo

Quality of life ‐ not measured · participants with cancer treated with chemotherapy

The review found no eligible studies for this question.

1 finding from 1 review

Probiotics for the prevention or treatment of chemotherapy‐ or radiotherapy‐related diarrhoea in people with cancer 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Probiotics vs placebo

Diarrhoea (grade 2+) · participants with cancer treated with chemotherapy

Probiotics showed no clear difference in diarrhoea grade 2 or higher compared with placebo (low certainty).

1 finding from 1 review

Probiotics for the prevention or treatment of chemotherapy‐ or radiotherapy‐related diarrhoea in people with cancer 2018 · Cochrane Headline outcomes only
RR 0.67 [0.22, 2.05]
1 study · 46 participants
Low