It is very uncertain whether taxane‐platinum‐fluoropyrimidine combinations changes treatment discontinuation due to toxicity compared with taxane‐platinum (without fluoropyrimidine) (very low certainty).
S‐1 showed no clear difference in overall Survival compared with 5‐FU‐containing regimens (high certainty).
It is very uncertain whether S‐1 changes tumour response compared with 5‐FU‐containing regimens (very low certainty).
S‐1 showed no clear difference in progression‐free survival compared with 5‐FU‐containing regimens (low certainty).
S‐1 showed no clear difference in time‐to treatment failure compared with 5‐FU‐containing regimens (low certainty).
S‐1 showed no clear difference in treatment‐related deaths compared with 5‐FU‐containing regimens (moderate certainty).
S‐1 showed no clear difference in treatment discontinuation due to toxicity compared with 5‐FU‐containing regimens (high certainty).
5‐FU/cisplatin/anthracycline combinations probably leads to lower overall survival compared with 5‐FU/cisplatin combinations (without anthracyclines) (moderate certainty).
5‐FU/cisplatin/anthracycline combinations may leads to higher tumour response compared with 5‐FU/cisplatin combinations (without anthracyclines) (low certainty).
5‐FU/cisplatin/anthracycline combinations may leads to lower time to progression compared with 5‐FU/cisplatin combinations (without anthracyclines) (low certainty).
The intervention showed no clear difference in eradication proportion (moderate certainty).
The intervention showed no clear difference in geographic region (low certainty).
The intervention showed no clear difference in publication date (moderate certainty).
The intervention showed no clear difference in STT length (high certainty).
It is very uncertain whether the intervention changes bacterial antibiotic resistance (very low certainty).
The intervention showed no clear difference in adverse events rate (high certainty).
The intervention probably leads to lower overall survival Hazard ratio (moderate certainty).
The intervention probably leads to higher complete resection (R0) Histology (moderate certainty).
The intervention showed no clear difference in local‐regional recurrence Radiology (moderate certainty).
The intervention showed no clear difference in distant recurrence Radiology (moderate certainty).