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What do systematic reviews say?

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Evidence found and GRADE certainty

578 questions · 600 findings · 55 reviews · Headline outcomes only

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No studies found 143 · 23.8%GRADE not reported 69 · 11.5%Very low 100 · 16.7%Low 142 · 23.7%Moderate 116 · 19.3%High 30 · 5%

Bilateral lateral rectus recession vs lateral rectus recession and medial rectus resection

Minor adverse events Defined as any adverse event within 8 weeks of surgery that does not require further intervention · people with intermittent exotropia, aged 3 to < 11 years

Bilateral lateral rectus recession showed no clear difference in minor adverse events Defined as any adverse event within 8 weeks of… compared with unilateral lateral rectus recession with medial rectus resection (low certainty).

1 finding from 1 review

Bilateral lateral rectus recession vs lateral rectus recession and medial rectus resection

Quality of life measures Measured at 3 years using the IXTQ scores for children, parents, or parent proxies (i.e. parents' perception of their children's quality of life). Scores could range from 0 (worst quality of life) to 100 (best quality of l... · people with intermittent exotropia, aged 3 to < 11 years
1 finding from 1 review

Patching vs active observation

Motor alignment at near fixation Measured using PACT at 6 months · people with intermittent exotropia, aged less than 11 years

Patching showed no clear difference in motor alignment at near fixation Measured using PACT at 6 months compared with active observation (high certainty).

1 finding from 1 review

Patching vs active observation

Stereoacuity at near · people with intermittent exotropia, aged less than 11 years

Patching showed no clear difference in stereoacuity at near Measured using the Preschool Randot, Titmus… compared with active observation (low certainty).

1 finding from 1 review

Cilostazol vs pentoxifylline

Adverse event related to study medication ‐ headache (number of cases) · intermittent claudication

Cilostazol may leads to higher adverse event related to study medication ‐ headache (number of cases) compared with pentoxifylline (low certainty).

1 finding from 1 review

Cilostazol vs placebo

Arterial revascularisation · intermittent claudication

It is very uncertain whether cilostazol changes arterial revascularisation (number of cases) compared with placebo (very low certainty).

1 finding from 1 review

Cilostazol vs placebo

Amputation · intermittent claudication

It is very uncertain whether cilostazol changes amputation (number of cases) compared with placebo (very low certainty).

1 finding from 1 review

Cilostazol vs placebo

Adverse event related to study medication ‐ headache (number of cases) · intermittent claudication

Cilostazol probably leads to higher adverse event related to study medication ‐ headache (number of cases) compared with placebo (moderate certainty).

1 finding from 1 review

Cilostazol vs placebo

Cardiovascular events · intermittent claudication

Cilostazol showed no clear difference in cardiovascular event (number of cases) compared with placebo (low certainty).

1 finding from 1 review