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Evidence found and GRADE certainty

1,125 questions · 1,173 findings · 91 reviews · Headline outcomes only

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No studies found 192 · 16.4%GRADE not reported 47 · 4%Very low 199 · 17%Low 325 · 27.7%Moderate 271 · 23.1%High 139 · 11.8%

Summary of findings table ‐ Platinum‐sensitive recurrent EOC: PARPi with chemotherapy vs chemotherapy alone

Progression‐free survival · platinum‐sensitive recurrent EOC

It is very uncertain whether summary of findings table ‐ Platinum‐sensitive recurrent EOC: PARPi… changes progression‐free survival (PFS) compared with chemotherapy alone (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Platinum‐sensitive recurrent EOC: PARPi with chemotherapy vs chemotherapy alone

Adverse events (grade ≥ 3) · platinum‐sensitive recurrent EOC

Summary of findings table ‐ Platinum‐sensitive recurrent EOC: PARPi… showed no clear difference in any severe adverse event (grade 3 or higher) (G3+ SevAE) compared with chemotherapy alone (low certainty).

1 finding from 1 review

Single‐dose intravesical chemotherapy instillation vs placebo or observation after nephroureterectomy

Time to bladder cancer recurrence (absolute effect size estimates based on recurrence rate at 12 months)

Single‐dose intravesical chemotherapy instillation may leads to lower time to bladder cancer recurrence (absolute effect size estimates… compared with placebo or observation after nephroureterectomy (low certainty).

1 finding from 1 review

Hysterectomy (radical) with neoadjuvant chemotherapy vs chemoradiotherapy alone

Death (all causes) · women with locally advanced cervical cancer

Hysterectomy (radical) with neoadjuvant chemotherapy showed no clear difference in overall survival Median compared with chemoradiotherapy alone (moderate certainty).

1 finding from 1 review

Hysterectomy (radical) with neoadjuvant chemotherapy vs chemoradiotherapy alone

SAEs and toxicity · women with locally advanced cervical cancer

It is very uncertain whether hysterectomy (radical) with neoadjuvant chemotherapy changes SAEs and toxicity compared with chemoradiotherapy alone (very low certainty).

1 finding from 1 review

Perioperative chemotherapy vs primary surgery

Overall survival among all patients · resectable adenocarcinoma of the stomach, gastroesophageal junction, and lower esophagus

Perioperative chemotherapy leads to lower overall survival among all patients compared with primary surgery (high certainty).

1 finding from 1 review

Perioperative chemotherapy vs primary surgery

Presence of tumor‐free resection margin · resectable adenocarcinoma of the stomach, gastroesophageal junction, and lower esophagus

Perioperative chemotherapy showed no clear difference in presence of tumor‐free resection margin compared with primary surgery (moderate certainty).

1 finding from 1 review

Perioperative chemotherapy vs primary surgery

Tumor stage at resection (T0 to T2 vs T3 to T4) · resectable adenocarcinoma of the stomach, gastroesophageal junction, and lower esophagus

Perioperative chemotherapy probably leads to higher tumor stage at resection (T0 to T2 vs T3 to T4) compared with primary surgery (moderate certainty).

1 finding from 1 review

Perioperative chemotherapy vs primary surgery

Tumor stage at resection (N0 vs N+) · resectable adenocarcinoma of the stomach, gastroesophageal junction, and lower esophagus

Perioperative chemotherapy may leads to higher tumor stage at resection (N0 vs N+) compared with primary surgery (low certainty).

1 finding from 1 review