Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,710 questions · 14,842 findings · 1,394 reviews

No studies found 2,880 · 19.4%GRADE not reported 1,413 · 9.5%Very low 3,103 · 20.9%Low 3,870 · 26.1%Moderate 2,663 · 17.9%High 913 · 6.2%

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Albendazole vs placebo or no anthelmintics

Seizure recurrence ‐ participants with a single cyst · people with neurocysticercosis

Albendazole probably leads to lower seizure recurrence ‐ participants with a single cyst compared with placebo or no anthelmintics (moderate certainty).

1 finding from 1 review

Albendazole vs placebo or no anthelmintics

Seizure recurrence ‐ participants with multiple (> 1) cysts · people with neurocysticercosis

It is very uncertain whether albendazole changes seizure recurrence ‐ participants with multiple (> 1) cysts compared with placebo or no anthelmintics (very low certainty).

1 finding from 1 review

Dornase alfa vs placebo or no dornase alfa treatment

FVC (% predicted) Change from baseline · adults and children with cystic fibrosis

Dornase alfa leads to higher relative mean percentage change in FVC (% predicted) at 6 months compared with placebo or no dornase alfa treatment (high certainty).

1 finding from 1 review

Dornase alfa vs placebo or no dornase alfa treatment

Quality of life: CFQ‐R respiratory domain: absolute change from baseline · adults and children with cystic fibrosis

Dornase alfa showed no clear difference in change in quality of life ‐ CFQ‐R respiratory at 1 month compared with placebo or no dornase alfa treatment (low certainty).

2 findings from 1 review

Dornase alfa vs placebo or no dornase alfa treatment

Exacerbations · adults and children with cystic fibrosis

Dornase alfa probably leads to lower number of people experiencing exacerbations at up to 2 years compared with placebo or no dornase alfa treatment (moderate certainty).

1 finding from 1 review

Systemic corticosteroids vs placebo or control

Mortality Mortality at latest · preterm infants with chronic lung disease

Systemic corticosteroids (dexamethasone or hydrocortisone) leads to lower mortality at latest reported age compared with control (placebo or nothing) (high certainty).

1 finding from 1 review

Systemic corticosteroids vs placebo or control

Bronchopulmonary dysplasia/chronic lung disease · preterm infants with chronic lung disease

Systemic corticosteroids (dexamethasone or hydrocortisone) probably leads to lower BPD at 36 weeks' PMA compared with control (placebo or nothing) (moderate certainty).

1 finding from 1 review

Systemic corticosteroids vs placebo or control

Death or bronchopulmonary dysplasia at 36 weeks PMA · preterm infants with chronic lung disease

Systemic corticosteroids (dexamethasone or hydrocortisone) probably leads to lower mortality or BPD at 36 weeks' PMA compared with control (placebo or nothing) (moderate certainty).

1 finding from 1 review