Dornase alfa vs placebo or no dornase alfa treatment: Quality of life: CFQ‐R respiratory domain: absolute change from baseline
Dornase alfa showed no clear difference in change in quality of life ‐ CFQ‐R respiratory at 1 month compared with placebo or no dornase alfa treatment (low certainty).
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Dornase alfa vs placebo or no dornase alfa treatment Change in quality of life ‐ CFQ‐R respiratory at 1 month · Adults and children with cystic fibrosis Dornase alfa showed no clear difference in change in quality of life ‐ CFQ‐R respiratory at 1 month compared with placebo or no dornase alfa treatment (low certainty). Dornase alfa for cystic fibrosis (2021) · Cochrane Headline outcomes only | MD 0.84 | 19 participants | Low |
Dornase alfa vs placebo or no dornase alfa treatment Change in quality of life ‐ CFQ‐R respiratory (parent) at 1 month · Adults and children with cystic fibrosis Dornase alfa showed no clear difference in change in quality of life ‐ CFQ‐R respiratory (parent) at 1 month compared with placebo or no dornase alfa treatment (low certainty). Dornase alfa for cystic fibrosis (2021) · Cochrane Headline outcomes only | MD 9.78 | 19 participants | Low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Dornase alfa for cystic fibrosis 2021 · Cochrane Headline outcomes only | Not reported | list not extracted yet | Not assessed |
Studies behind the findings
None of these reviews ties its included studies to this outcome in the data here. Cochrane reviews and reviews with headline outcomes only do not list their studies yet.
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.