Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,815 questions · 6,211 findings · 638 reviews · Headline outcomes only

No studies found 1,052 · 16.9%GRADE not reported 441 · 7.1%Very low 1,700 · 27.4%Low 1,651 · 26.6%Moderate 1,070 · 17.2%High 297 · 4.8%

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Intervention not reported

Non‐nicotine/placebo EC · adults (aged ≥ 18 years) who smoked cigarettes Components: components of pharmacological and e‐cigarette (EC) interventions for smoking…

The intervention showed no clear difference in non‐nicotine/placebo EC (low certainty).

1 finding from 1 review

Intervention not reported

Nortriptyline · adults (aged ≥ 18 years) who smoked cigarettes Components: components of pharmacological and e‐cigarette (EC) interventions for smoking…

The intervention probably leads to higher nortriptyline (moderate certainty).

1 finding from 1 review

Shunting vs no shunting

Stroke‐related death within 30 days of surgery (best‐case) · patients with symptomatic or asymptomatic carotid disease

Shunting may leads to lower stroke‐related death within 30 days of surgery (best‐case) compared with no shunting (low certainty).

1 finding from 1 review

Shunting vs no shunting

Stroke‐related death within 30 days of surgery (worst‐case) · patients with symptomatic or asymptomatic carotid disease

Shunting showed no clear difference in stroke‐related death within 30 days of surgery (worst‐case) compared with no shunting (low certainty).

1 finding from 1 review

Mifepristone (600 mg) plus prostaglandin vs mifepristone (200 mg) plus prostaglandin

Failure to achieve complete abortion · women undergoing first trimester abortion

Mifepristone (600 mg) plus prostaglandin showed no clear difference in failure to achieve complete abortion compared with mifepristone (200 mg) plus prostaglandin (moderate certainty).

1 finding from 1 review

Oral misoprostol vs vaginal misoprostol

Failure to achieve complete abortion · women undergoing first trimester abortion

Oral misoprostol probably leads to higher failure to achieve complete abortion compared with vaginal misoprostol (moderate certainty).

2 findings from 1 review