Findings

What do systematic reviews say?

4,411 questions · 5,986 findings · 226 reviews · Oral Health

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No studies found 1,305 · 21.8%GRADE not reported 2,988 · 49.9%Very low 1,030 · 17.2%Low 476 · 8%Moderate 156 · 2.6%High 31 · 0.5%

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Topical treatments (benzydamine hydrochloride oral rinse) vs placebo

Adverse effects · People with primary burning mouth syndrome (BMS), that is, oral mucosal pain with no dental or medical cause for such symptoms

1 finding from 1 review

Interventions for treating burning mouth syndrome 2016 · Cochrane All outcomes
short-term (up to 3 months) · benzydamine hydrochloride
SoF9. Adverse effects: single study narratively reported that no adverse effects occurred from benzydamine hydrochloride oral rinse; 20 participants (1 RCT); very low.
1 study · 20 participants
Very low

Mineral trioxide aggregate (MTA) root-end filling vs Intermediate restorative material (IRM)

Healing rate · People requiring retreatment of periapical lesions (failed root canal therapy)

Mineral trioxide aggregate (MTA) root-end filling showed no clear difference in healing - 2 years compared with intermediate restorative material (IRM); GRADE not reported.

1 finding from 1 review

Endodontic procedures for retreatment of periapical lesions 2016 · Cochrane All outcomes
2 years
RR 1.05 [0.92, 1.20]
1 study · 108 participants
GRADE not reported

Preoperative analgesics (analgesics given before dental treatment) vs Placebo or no analgesics

Anxiety · Children and adolescents aged up to 17 years having dental treatment (orthodontic treatment, fillings, pulp treatment, or tooth…

The review found no eligible studies for this question.

1 finding from 1 review

Preoperative analgesics for additional pain relief in children and adolescents having dental treatment 2016 · Cochrane All outcomes
None of the included studies assessed anxiety or behaviour at baseline, and none recorded baseline anxiety. PUB3: 'The [three/four] studies did not measure ... preoperative and postoperative anxiety measures ...'
0 studies
No studies found

Platelet-rich fibrin (PRF) graft vs No grafting

Postoperative pain · People requiring retreatment of periapical lesions (failed root canal therapy)

1 finding from 1 review

Endodontic procedures for retreatment of periapical lesions 2016 · Cochrane All outcomes
up to 7 days
Pain not assessed by VAS; reported significantly less in the PRF group at two time points only (2 and 6 hours after surgery).
1 study · 11 participants
GRADE not reported

Dietary supplements (Catuama herbal compound) vs placebo

Adverse effects: exacerbation of symptoms · People with primary burning mouth syndrome (BMS), that is, oral mucosal pain with no dental or medical cause for such symptoms

It is very uncertain whether dietary supplements (Catuama herbal compound) changes adverse effects: exacerbation of symptoms compared with placebo (very low certainty).

1 finding from 1 review

Interventions for treating burning mouth syndrome 2016 · Cochrane All outcomes
short-term (up to 3 months) · Catuama
RR 1.12 [0.33, 3.83]
1 study · 72 participants
Very low

Chemically cured zinc phosphate cement vs Glass ionomer cement (GIC)

Band failure (band adhesive loosening) · Patients with full arch fixed orthodontic appliances with bands attached to molars (patients with cleft lip/palate or other craniofacial…

1 finding from 1 review

Adhesives for fixed orthodontic bands 2016 · Cochrane All outcomes
Approximately 12 months (to end of treatment)
No meta-analysis (band failure not reported on a per-patient basis). Durning 1989 (69 participants): at ~12 months failure rate 34.78% (zinc phosphate) vs 26% (glass ionomer), P > 0.05; mean survival time 470.9 vs…
4 studies
GRADE not reported

Educational intervention with information and practical components (theoretical oral health education plus practical skills training) for nursing staff and/or residents vs usual care

Adverse events: Clinically important specific adverse events · People with serious mental illness (all included participants had schizophrenia); majority aged 18 to 65 years per NIMH 1987, or with…

The review found no eligible studies for this question.

1 finding from 1 review

Oral health education (advice and training) for people with serious mental illness 2016 · Cochrane All outcomes
No study reported useable data
0 studies
No studies found

Perioperative infraorbital nerve block vs Infiltration of the incision (peri-incisional infiltration)

Length of hospital stay · Children up to 13 years of age, undergoing cleft lip repair surgery

The review found no eligible studies for this question.

1 finding from 1 review

Infraorbital nerve block for postoperative pain following cleft lip repair in children 2016 · Cochrane All outcomes
The included studies did not report this outcome.
0 studies
No studies found

Educational intervention with information and practical components (theoretical oral health education plus practical skills training) for nursing staff and/or residents vs (Optimised) usual care

Incidence of respiratory diseases and pneumonia · Nursing home residents (mean age 78.3 to 86.0 years; more than 66% women; 62.1% to 87.3% with dental prostheses)

The review found no eligible studies for this question.

1 finding from 1 review

Oral health educational interventions for nursing home staff and residents 2016 · Cochrane All outcomes
None of the included studies assessed incidence of respiratory diseases or pneumonia.
0 studies
No studies found

Oral appliance or functional orthopaedic appliance vs placebo or no treatment

Daytime symptom: thirstiness in the morning (questionnaire) · Children with obstructive sleep apnoea (aged 15 years or younger)

Oral appliance or functional orthopaedic appliance showed no clear difference in daytime symptom: thirstiness in the morning (questionnaire) compared with placebo or no treatment; GRADE not reported.

1 finding from 1 review

Oral appliances and functional orthopaedic appliances for obstructive sleep apnoea in children 2016 · Cochrane All outcomes
6 months
RR 0.16 [0.02, 1.22]
1 study · 23 participants
GRADE not reported

Oral appliance or functional orthopaedic appliance vs placebo or no treatment

Signs and symptoms of atypical swallowing and speech production disturbances · Children with obstructive sleep apnoea (aged 15 years or younger)

The review found no eligible studies for this question.

1 finding from 1 review

Oral appliances and functional orthopaedic appliances for obstructive sleep apnoea in children 2016 · Cochrane All outcomes
The included study did not assess this outcome.
0 studies
No studies found

Educational intervention with information only (theoretical dental health education, no practical training) vs usual care

Denture-induced stomatitis · Residents of institutions for elderly people (nursing staff and residents took part in the education programme)

1 finding from 1 review

Oral health educational interventions for nursing home staff and residents 2016 · Cochrane All outcomes
Schou 1989 (114 residents, unclear risk of bias): no difference in the prevalence of denture stomatitis between the groups.
1 study · 114 participants
GRADE not reported

Perioperative infraorbital nerve block vs Intravenous analgesia

Length of hospital stay · Children up to 13 years of age, undergoing cleft lip repair surgery

The review found no eligible studies for this question.

1 finding from 1 review

Infraorbital nerve block for postoperative pain following cleft lip repair in children 2016 · Cochrane All outcomes
None of the included studies reported this outcome.
0 studies
No studies found

Perioperative infraorbital nerve block vs Intravenous analgesia

Pain measured by valid instruments (mean postoperative pain score) · Children up to 13 years of age, undergoing cleft lip repair surgery

It is very uncertain whether perioperative infraorbital nerve block changes pain measured by valid instruments (mean postoperative pain score) compared with intravenous analgesia (very low certainty).

1 finding from 1 review

Infraorbital nerve block for postoperative pain following cleft lip repair in children 2016 · Cochrane All outcomes
0 to 4 hours (first four hours after surgery)
SMD -1.50 [-2.40, -0.60]
2 studies · 107 participants
Very low

Perioperative infraorbital nerve block vs Infiltration of the incision (peri-incisional infiltration)

Need for analgesic prescription for pain (supplemental analgesic requirements) · Children up to 13 years of age, undergoing cleft lip repair surgery

It is very uncertain whether perioperative infraorbital nerve block changes need for analgesic prescription for pain (supplemental analgesic… compared with infiltration of the incision (peri-incisional infiltration) (very low certainty).

1 finding from 1 review

Infraorbital nerve block for postoperative pain following cleft lip repair in children 2016 · Cochrane All outcomes
RR 0.16 [0.05, 0.51]
1 study · 30 participants
Very low

Monitoring (any means of observation, supervision, keeping under review, measuring or testing at intervals) vs No monitoring

Quality of life: Chronic pain · People with serious mental illness (all included participants had schizophrenia); majority aged 18 to 65 years per NIMH 1987, or with…

The review found no eligible studies for this question.

1 finding from 1 review

Oral health education (advice and training) for people with serious mental illness 2016 · Cochrane All outcomes
No study reported useable data
0 studies
No studies found

Vitamin A or retinoids (systemic or topical; incl. 13-cis-retinoic acid, acitretin) vs placebo or no treatment

Clinical resolution (oral lesion not completely resolved) · People with a diagnosis of oral leukoplakia

1 finding from 1 review

Interventions for treating oral leukoplakia to prevent oral cancer 2016 · Cochrane All outcomes
4 to 12 months
SoF 1, Clinical resolution (not completely resolved) at 4 to 12 months: 'Studies could not be combined in meta-analysis. One study evaluated topical treatment and did not find evidence of benefit; 3 studies of systemic…
4 studies
GRADE not reported

Low‐level laser therapy vs Placebo (or no irradiation)

Adverse effects of pain treatment · Adolescents and adults undergoing orthodontic treatment

The review found no eligible studies for this question.

1 finding from 1 review

Non‐pharmacological interventions for alleviating pain during orthodontic treatment 2016 · Cochrane All outcomes
Adverse effects: Not measured.
Studies not reported
No studies found

Oral appliance or functional orthopaedic appliance vs placebo or no treatment

Reduction of apnoea episodes (apnoea-hypopnoea index) · Children with obstructive sleep apnoea (aged 15 years or younger)

It is very uncertain whether oral appliance or functional orthopaedic appliance changes reduction of apnoea episodes (apnoea-hypopnoea index) compared with placebo or no treatment (very low certainty).

1 finding from 1 review

Oral appliances and functional orthopaedic appliances for obstructive sleep apnoea in children 2016 · Cochrane All outcomes
6 months
RR 0.39 [0.20, 0.76]
1 study · 23 participants
Very low

Perioperative infraorbital nerve block vs Placebo (sham/placebo device)

Analgesia durationTime duration from the end of surgery to the time of first analgesic consumption. Scale from: 0 to 100. · Children up to 13 years of age, undergoing cleft lip repair surgery

1 finding from 1 review

Infraorbital nerve block for postoperative pain following cleft lip repair in children 2016 · Cochrane All outcomes
Takmaz 2009: time to first analgesic requirement significantly longer in the intervention than the placebo group (8.3 +/- 0.9 hours versus 1.6 +/- 0.8 hours; P = 0.001). Not pooled.
1 study
GRADE not reported