Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,097 questions · 3,266 findings · 631 reviews

No studies found 430 · 13.2%GRADE not reported 193 · 5.9%Very low 995 · 30.5%Low 904 · 27.7%Moderate 591 · 18.1%High 153 · 4.7%

Intervention not reported

Mortality in children with HIV infection ‐ isoniazid prophylaxis only · children with HIV infection aged 12 years and under

The intervention showed no clear difference in mortality in children with HIV infection ‐ isoniazid prophylaxis only (low certainty).

1 finding from 1 review

Intervention not reported

Incidence of adverse events ‐ co‐trimoxazole prophylaxis only · children with HIV infection aged 12 years and under

The intervention showed no clear difference in incidence of adverse events ‐ co‐trimoxazole prophylaxis only (moderate certainty).

1 finding from 1 review

Intervention not reported

Incidence of Pseudomonas infection in children with cystic fibrosis ‐ ciprofloxacin prophylaxis only · children with cystic fibrosis aged 12 years and under

The intervention showed no clear difference in incidence of Pseudomonas infection in children with cystic fibrosis… (moderate certainty).

1 finding from 1 review

Intervention not reported

Child cognitive ability As assessed by the Griffith Mental Development scale at 18‐month · children younger than five years of age and their families

It is very uncertain whether the intervention changes child cognitive ability As assessed by the Griffith Mental… (very low certainty).

1 finding from 1 review

Intervention not reported

Child psychosocial development Parents reporting their child develops abnormally · children younger than five years of age and their families

It is very uncertain whether the intervention changes child psychosocial development Parents reporting their child… (very low certainty).

1 finding from 1 review

Intervention not reported

Paid maternal employment Mothers in full‐time or part‐time employment · children younger than five years of age and their families

It is very uncertain whether the intervention changes paid maternal employment Mothers in full‐time or part‐time employment (very low certainty).

1 finding from 1 review