Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,072 questions · 4,237 findings · 447 reviews · Headline outcomes only

No studies found 946 · 22.3%GRADE not reported 257 · 6.1%Very low 1,121 · 26.5%Low 1,207 · 28.5%Moderate 568 · 13.4%High 138 · 3.3%

DDAVP vs tranexamic acid (control)

All thrombotic events (including myocardial infarction, ischaemic stroke, other arterial thromboembolism, and venous thromboembolism) · participants undergoing surgery

It is very uncertain whether DDAVP changes all thrombotic events (including myocardial infarction, ischaemic… compared with tranexamic acid (very low certainty).

1 finding from 1 review

DDAVP vs placebo or usual care

Number of participants receiving a red cell transfusion (total) · participants undergoing surgery

DDAVP showed no clear difference in number of participants receiving a red cell transfusion (total) compared with placebo or standard care (moderate certainty).

1 finding from 1 review

DDAVP vs aprotinin

Number of participants receiving a red cell transfusion (total) · participants undergoing surgery

DDAVP may leads to higher number of participants receiving a red cell transfusion (total) compared with aprotinin (low certainty).

1 finding from 1 review

DDAVP vs placebo or usual care

Number of participants receiving a red cell transfusion (total) · participants with platelet dysfunction undergoing surgery

DDAVP showed no clear difference in number of participants receiving a red cell transfusion (total) compared with placebo or standard care: platelet dysfunction subgroup (low certainty).

1 finding from 1 review

Buffered vs non‐buffered crystalloid intravenous fluid

Mortality (in‐hospital death and 30‐day mortality) · adults receiving intravenous fluids whilst undergoing any form of surgery

Buffered showed no clear difference in mortality (in‐hospital death and 30‐day mortality) compared with non‐buffered crystalloid intravenous fluid (low certainty).

1 finding from 1 review

Buffered vs non‐buffered crystalloid intravenous fluid

Organ system failure ‐ renal insufficiency requiring support · adults receiving intravenous fluids whilst undergoing any form of surgery

Buffered showed no clear difference in organ system failure ‐ renal insufficiency requiring support compared with non‐buffered crystalloid intravenous fluid (low certainty).

1 finding from 1 review