Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,703 questions · 3,824 findings · 858 reviews

No studies found 573 · 15%GRADE not reported 383 · 10%Very low 993 · 26%Low 1,062 · 27.8%Moderate 614 · 16.1%High 199 · 5.2%

Human recombinant activated protein C vs placebo

28‐Day all‐cause mortality (adult and paediatric patients) · patients with severe sepsis or septic shock

Human recombinant activated protein C showed no clear difference in 28‐Day all‐cause mortality (adult and paediatric patients) compared with placebo (moderate certainty).

1 finding from 1 review

Human recombinant activated protein C vs placebo

Serious bleeding events in adult and paediatric patients (days 0 to 28) · patients with severe sepsis or septic shock

Human recombinant activated protein C probably leads to higher serious bleeding events in adult and paediatric patients (days 0 to… compared with placebo (moderate certainty).

1 finding from 1 review

Summary of findings table ‐ Recombinant activated factor VII vs placebo

Mortality within 5 days · patients with upper gastrointestinal bleeding and liver diseases.

Recombinant human factor VII activated showed no clear difference in mortality within 5 days compared with placebo (moderate certainty).

1 finding from 1 review

Summary of findings table ‐ Recombinant activated factor VII vs placebo

Mortality within 42 days · patients with upper gastrointestinal bleeding and liver diseases.

Recombinant human factor VII activated showed no clear difference in mortality within 42 days compared with placebo (moderate certainty).

1 finding from 1 review

Social cognitive theory for promotion of condom use vs no intervention

Consistent application of condom by FSWs · sex workers

Social cognitive theory for promotion of condom use showed no clear difference in consistent condom use by FSWs with clients in the past 7‐day compared with no intervention (moderate certainty).

1 finding from 1 review

Human deoxyribonuclease vs placebo

Clinical failure Number of children with no significant improvement in cough diary scores at two weeks (average of day 13 to 14) · children with primary (intrinsic) tracheomalacia

Human deoxyribonuclease showed no clear difference in clinical failure Number of children with no significant improvement… compared with placebo (low certainty).

1 finding from 1 review

Intervention not reported

Inpatient and 30 day mortality ‐ Colon cancer · Patients with outcomes after colorectal cancer surgery

It is very uncertain whether the intervention changes inpatient and 30 day mortality ‐ Colon cancer (very low certainty).

1 finding from 1 review

Intervention not reported

Inpatient and 30 day mortality ‐ Rectal cancer · Patients with outcomes after colorectal cancer surgery

The intervention showed no clear difference in inpatient and 30 day mortality ‐ Rectal cancer (low certainty).

1 finding from 1 review

Intervention not reported

Inpatient and 30 day mortality ‐ Colorectal cancer · Patients with outcomes after colorectal cancer surgery

The intervention may leads to lower inpatient and 30 day mortality ‐ Colorectal cancer (low certainty).

1 finding from 1 review

Intervention not reported

Inpatient and 30 day mortality ‐ Colorectal cancer · Patients with outcomes after colorectal cancer surgery

It is very uncertain whether the intervention changes inpatient and 30 day mortality ‐ Colorectal cancer (very low certainty).

1 finding from 1 review

Intervention not reported

Inpatient and 30 day mortality ‐ Colon cancer · Patients with outcomes after colorectal cancer surgery

It is very uncertain whether the intervention changes inpatient and 30 day mortality ‐ Colon cancer (very low certainty).

1 finding from 1 review

Intervention not reported

Inpatient and 30 day mortality ‐ Rectal cancer · Patients with outcomes after colorectal cancer surgery

It is very uncertain whether the intervention changes inpatient and 30 day mortality ‐ Rectal cancer (very low certainty).

1 finding from 1 review

Intervention not reported

Neurological sequelae at day 28 · Children with severe malaria

The intervention showed no clear difference in neurological sequelae at day 28 (moderate certainty).

1 finding from 1 review

Intervention not reported

Neurological sequelae at day 28 · Adults with severe malaria

The review found no eligible studies for this question.

1 finding from 1 review