Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

492 questions · 535 findings · 56 reviews · Hypertension

No studies found 37 · 6.9%GRADE not reported 34 · 6.4%Very low 91 · 17%Low 161 · 30.1%Moderate 136 · 25.4%High 76 · 14.2%

Effect of medium‐dose alcohol vs placebo

Diastolic blood pressure · adult participants
3 findings from 1 review

Any antihypertensive drug vs placebo or no treatment

Cardiovascular mortality and morbidity Mean duration of 3.7 years · adults 60 years or older with primary hypertension

Antihypertensive drug probably leads to lower cardiovascular mortality and morbidity Mean duration of 3.7 years compared with placebo or no treatment (moderate certainty).

1 finding from 1 review

Any antihypertensive drug vs placebo or no treatment

Coronary heart disease mortality + morbidity · adults 60 years or older with primary hypertension

Antihypertensive drug probably leads to lower coronary heart disease mortality and morbidity Mean duration of 2.9… compared with placebo or no treatment (moderate certainty).

1 finding from 1 review

First‐line beta‐blocker vs placebo

Total coronary heart disease · adults with primary hypertension

First‐line beta‐blocker showed no clear difference in total coronary heart disease compared with placebo (low certainty).

1 finding from 1 review

First‐line beta‐blocker vs placebo

Withdrawals due to adverse events · adults with primary hypertension

First‐line beta‐blocker may leads to higher withdrawal due to adverse effects compared with placebo (low certainty).

1 finding from 1 review