Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

322 questions · 324 findings · 25 reviews · Eyes and Vision

No studies found 77 · 23.8%GRADE not reported 5 · 1.5%Very low 77 · 23.8%Low 64 · 19.8%Moderate 91 · 28.1%High 10 · 3.1%

Omega‐3 vs placebo

Change in visual loss associated with PSR: visual loss is defined by the deterioration of visual acuity of 3 lines or more with the Snellen chart · people with AMD

Omega 3 fatty acids probably leads to higher loss of 3 or more lines of VA at 24 months compared with placebo (moderate certainty).

2 findings from 1 review

Intraoperative 5‐Fluorouracil vs placebo or control

Failure at 12 months Need for repeat surgery or uncontrolled IOP (usually more than 22 mm Hg) despite additional topical or systemic medications · participants with glaucoma surgery

Intraoperative 5‐Fluorouracil leads to lower failure at 12 months Need for repeat surgery or uncontrolled IOP… compared with placebo or control (high certainty).

1 finding from 1 review