evidence/gaps
Cochrane · systematic review · CD007685

Sublingual immunotherapy for treating allergic conjunctivitis

Calderon, MA, Penagos, M, Sheikh, A, et al. · Cochrane Database of Systematic Reviews · 2011 · Cochrane Library

Eyes and VisionAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 7 · 100%High 0 · 0%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

Questions and results

Sublingual immunotherapy versus placebo for allergic conjunctivitis

Population: patients with allergic conjunctivitis
7 questions
OutcomeEffectEvidenceStatus / GRADE
Total ocular symptom scores Symptom scores
Sublingual immunotherapy vs placebo
no estimate extracted36 studies · 3399 participantsModerate
Downgraded: imprecision
Itchy/Gritty eyes Symptom scores
Sublingual immunotherapy vs placebo
no estimate extracted28 studies · 3020 participantsModerate
Watery eyes Symptom scores
Sublingual immunotherapy vs placebo
no estimate extracted21 studies · 2641 participantsModerate
Red eyes Symptom scores
Sublingual immunotherapy vs placebo
no estimate extracted20 studies · 1211 participantsModerate
Eye drops Symptom scores
Sublingual immunotherapy vs placebo
no estimate extracted13 studies · 1038 participantsModerate
Downgraded: publication bias
Combined symptom‐medication scores Symptom scores
Sublingual immunotherapy vs placebo
no estimate extracted3 studies · 351 participantsModerate
Downgraded: inconsistency
Conjunctival immediate allergen sensitivity Symptom scores
Sublingual immunotherapy vs placebo
no estimate extracted4 studies · 250 participantsModerate
Downgraded: publication bias