Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,801 questions · 4,079 findings · 473 reviews

No studies found 669 · 16.4%GRADE not reported 852 · 20.9%Very low 738 · 18.1%Low 903 · 22.1%Moderate 716 · 17.6%High 201 · 4.9%

Older adults (population mean age >33.4 years) vs Younger adults (population mean age <=33.4 years)

Caries experience (mean DMFT) · Adults aged 19-60 years

Studies of older adults (mean age >33.4 years) had higher pooled DMFT than younger adults, but the age to DMFT meta-regression was not statistically significant; ungraded observational evidence.

5 findings from 1 review
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Genetically predicted pulp and periapical diseases vs Without pulp and periapical diseases (lower genetic liability)

Lacunar stroke · European-ancestry adults

Genetically predicted pulp and periapical diseases were associated with modestly higher odds of lacunar stroke (OR 1.20); ungraded MR, FDR-adjusted P 0.033.

1 finding from 1 review

38% SDF (indirect pulp capping under resin composite) vs Resin-modified glass ionomer cement (RMGIC)

Secondary caries prevention in young permanent first molars · Children with deep occlusal caries in young permanent first molars (indirect pulp capping)

SDF and RMGIC did not differ significantly for secondary caries prevention in young permanent molars (no events; p>0.05; ungraded).

1 finding from 1 review

38% SDF plus potassium iodide (KI) (indirect pulp capping) vs Resin-modified glass ionomer cement (RMGIC)

Secondary caries prevention in young permanent first molars · Children with deep occlusal caries in young permanent first molars (indirect pulp capping)

SDF+KI and RMGIC did not differ significantly for secondary caries prevention (p>0.05; ungraded).

1 finding from 1 review

38% SDF plus potassium iodide (KI) (indirect pulp capping) vs Resin-modified glass ionomer cement (RMGIC)

Secondary prevention of caries · children with deep occlusal carious lesions in permanent molars

No significant difference in secondary caries prevention was reported; no effect estimate or GRADE rating was reported.

1 finding from 1 review

Duplex ultrasound plus pulse palpation and arterial pressure index (ABI or TBI) vs pulse palpation plus arterial pressure index (ABI or TBI) (short term)

Limb salvage · people who underwent a lower limb revascularisation

Duplex ultrasound plus pulse palpation and arterial pressure index… showed no clear difference in limb salvage rate compared with pulse palpation plus arterial pressure index (ABI or TBI) (short term) (low certainty).

1 finding from 1 review

Duplex ultrasound plus pulse palpation and arterial pressure index (ABI or TBI) vs pulse palpation plus arterial pressure index (ABI or TBI) (short term)

Secondary patency (24 months) · people who underwent a lower limb revascularisation

Duplex ultrasound plus pulse palpation and arterial pressure index… showed no clear difference in vessel or graft secondary patency compared with pulse palpation plus arterial pressure index (ABI or TBI) (short term) (low certainty).

1 finding from 1 review

Duplex ultrasound plus pulse palpation and arterial pressure index (ABI or TBI) vs pulse palpation plus arterial pressure index (ABI or TBI) (short term)

All‐cause mortality · people who underwent a lower limb revascularisation

Duplex ultrasound plus pulse palpation and arterial pressure index… showed no clear difference in all‐cause mortality compared with pulse palpation plus arterial pressure index (ABI or TBI) (short term) (low certainty).

1 finding from 1 review

Duplex ultrasound plus pulse palpation and arterial pressure index (ABI or TBI) vs pulse palpation plus arterial pressure index (ABI or TBI) (long term)

Secondary patency (24 months) · people who underwent a lower limb revascularisation

Duplex ultrasound plus pulse palpation and arterial pressure index… showed no clear difference in vessel or graft secondary patency compared with pulse palpation plus arterial pressure index (ABI or TBI) (long term) (low certainty).

1 finding from 1 review

Populations with low socioeconomic status (>=22.4% of the population with low SES) vs Populations with higher socioeconomic status (<22.4% of the population with low SES)

Caries experience (mean DMFT) · Adults aged 19-60 years

Populations with a higher proportion of people with low socioeconomic status had higher caries experience (pooled DMFT 15.99 vs 5.50), and meta-regression associated low SES with higher DMFT (about 10.35 more DMFT per unit; p=0.050); ungraded observational evidence.

5 findings from 1 review
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