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Evidence found and GRADE certainty

2,539 questions · 2,602 findings · 424 reviews · Headline outcomes only

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No studies found 572 · 22%GRADE not reported 189 · 7.3%Very low 527 · 20.3%Low 685 · 26.3%Moderate 514 · 19.8%High 115 · 4.4%

Summary of findings table ‐ Daratumumab plus standard therapy vs usual care

Mortality within the longest · people with newly diagnosed multiple myeloma ineligible for transplant

Summary of findings table ‐ Daratumumab plus standard therapy probably leads to lower on‐study mortality (longest available compared with standard therapy (moderate certainty).

1 finding from 1 review

Summary of findings table ‐ Daratumumab plus standard therapy vs usual care

Serious adverse events at longest · people with newly diagnosed multiple myeloma ineligible for transplant

Summary of findings table ‐ Daratumumab plus standard therapy probably leads to higher serious adverse events (longest available compared with standard therapy (moderate certainty).

1 finding from 1 review

Summary of findings table ‐ Daratumumab plus standard therapy vs usual care

Adverse events (grade ≥ 3) · people with newly diagnosed multiple myeloma ineligible for transplant

Summary of findings table ‐ Daratumumab plus standard therapy showed no clear difference in adverse events (CTCAE grade ≥ 3) (longest available compared with standard therapy (moderate certainty).

1 finding from 1 review

Summary of findings table ‐ Daratumumab plus standard therapy vs usual care

Adverse events: infections (CTCAE grade ≥ 3) (longest available · people with newly diagnosed multiple myeloma ineligible for transplant

Summary of findings table ‐ Daratumumab plus standard therapy probably leads to higher adverse events: infections (CTCAE grade ≥ 3) (longest available compared with standard therapy (moderate certainty).

1 finding from 1 review

Summary of findings: Any alternative model of care vs usual care

ED visits · Nursing home residents (mean age 78.3 to 86.0 years; more than 66% women; 62.1% to 87.3% with dental prostheses)

Summary of findings: Any alternative model of care showed no clear difference in emergency department (ED) visits: proportion of residents with at… compared with usual care (low certainty).

1 finding from 1 review

Summary of findings: Any alternative model of care vs usual care

Unplanned admission to hospital · Nursing home residents (mean age 78.3 to 86.0 years; more than 66% women; 62.1% to 87.3% with dental prostheses)

Summary of findings: Any alternative model of care may leads to lower unplanned hospital admissions: proportion of residents with at least… compared with usual care (low certainty).

1 finding from 1 review

Summary of findings: Any alternative model of care vs usual care

Falls · Nursing home residents (mean age 78.3 to 86.0 years; more than 66% women; 62.1% to 87.3% with dental prostheses)

It is very uncertain whether summary of findings: Any alternative model of care changes adverse events/falls: proportion of residents with a fall at longest compared with usual care (very low certainty).

1 finding from 1 review

Summary of findings: Any alternative model of care vs usual care

Adherence to clinical guideline‐recommended care: proportion of residents with adequate antidepressant therapy at longest · Nursing home residents (mean age 78.3 to 86.0 years; more than 66% women; 62.1% to 87.3% with dental prostheses)

It is very uncertain whether summary of findings: Any alternative model of care changes adherence to clinical guideline‐recommended care: proportion of… compared with usual care (very low certainty).

1 finding from 1 review

Summary of findings: Any alternative model of care vs usual care

Differences in quality of life ( · Nursing home residents (mean age 78.3 to 86.0 years; more than 66% women; 62.1% to 87.3% with dental prostheses)

Summary of findings: Any alternative model of care showed no clear difference in health‐related quality of life (mean difference) at longest compared with usual care (low certainty).

1 finding from 1 review

Summary of findings: Any alternative model of care vs usual care

Has died · Nursing home residents (mean age 78.3 to 86.0 years; more than 66% women; 62.1% to 87.3% with dental prostheses)

Summary of findings: Any alternative model of care showed no clear difference in mortality: proportion of residents who died at longest compared with usual care (moderate certainty).

1 finding from 1 review

Summary of findings table ‐ Endoscopic sphincterotomy vs sham

Proportion of participants without successful treatment at longest · adults with biliary sphincter of Oddi dysfunction

It is very uncertain whether summary of findings table ‐ Endoscopic sphincterotomy changes proportion of participants without successful treatment at longest compared with sham treatment (very low certainty).

1 finding from 1 review