Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

465 questions · 491 findings · 45 reviews

No studies found 117 · 23.8%GRADE not reported 35 · 7.1%Very low 131 · 26.7%Low 133 · 27.1%Moderate 61 · 12.4%High 14 · 2.9%

Peripartum/postnatal prophylaxis (caesarean): heparin (LMWH or UFH) vs no treatment/placebo

Symptomatic thromboembolic events ( · women giving birth by elective or emergency caesarean (elective only (1 trial), emergency or elective (4 trials))

It is very uncertain whether peripartum/postnatal prophylaxis (caesarean): heparin (LMWH or UFH) changes symptomatic thromboembolic events (timing of assessment unclear,… compared with no treatment/placebo (very low certainty).

1 finding from 1 review

Peripartum/postnatal prophylaxis (caesarean): heparin (LMWH or UFH) vs no treatment/placebo

Symptomatic PE · women giving birth by elective or emergency caesarean (elective only (1 trial), emergency or elective (4 trials))

It is very uncertain whether peripartum/postnatal prophylaxis (caesarean): heparin (LMWH or UFH) changes symptomatic PE (timing of assessment unclear, within 6 weeks… compared with no treatment/placebo (very low certainty).

1 finding from 1 review

Intervention not reported

Antibiotic versus heparin only lock/flush solution: catheter‐related infections · adults and children diagnosed with an oncologic disease with a newly‐inserted long‐term CVC who were at risk of neutropenia due to…

The intervention probably leads to lower antibiotic versus heparin only lock/flush solution: catheter‐related… (moderate certainty).

1 finding from 1 review

Summary of Findings Table ‐ Enoxaparin vs no enoxaparin

Adverse events: clinically relevant non‐major bleeding / heparin‐induced thrombocytopenia ‐ not reported · adults with acute lymphoblastic leukaemia treated with asparaginase‐based chemotherapy

The review found no eligible studies for this question.

1 finding from 1 review

Slow vs fast subcutaneous heparin injection

Bruise incidence ‐ 48 hours after injection · patients treated with subcutaneous heparin injections

Slow may leads to lower bruise incidence ‐ 48 hours after injection compared with fast subcutaneous heparin injection (low certainty).

2 findings from 1 review

Does normal saline flushing in long‐term central venous catheters (CVC) prevent occlusion vs heparin flushing

CVC occlusion rate per 1000 catheter days Ability to infuse solution through CVC · infants and children with a long‐term CVC

It is very uncertain whether does normal saline flushing in long‐term central venous catheters… changes CVC occlusion rate per 1000 catheter days: ability to infuse… compared with heparin flushing (very low certainty).

1 finding from 1 review

Does normal saline flushing in long‐term central venous catheters (CVC) prevent occlusion vs heparin flushing

CVC‐associated blood stream infection rate per 1000 catheter days Incidence of positive blood culture · infants and children with a long‐term CVC

Does normal saline flushing in long‐term central venous catheters… showed no clear difference in CVC‐associated blood stream infection rate per 1000 catheter days:… compared with heparin flushing (low certainty).

1 finding from 1 review