Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

329 questions · 345 findings · 47 reviews · Headline outcomes only

No studies found 93 · 27%GRADE not reported 8 · 2.3%Very low 44 · 12.8%Low 118 · 34.2%Moderate 75 · 21.7%High 7 · 2%

An extended NVP regimen administered to infants for 14 weeks vs sdNVP plus ZDV (1 week)

Infant Mortality at 24 months among those uninfected at birth · Breastfeeding infants of HIV‐infected mothers

An extended NVP regimen administered to infants for 14 weeks showed no clear difference in infant Mortality at 24 months among those uninfected at birth compared with sdNVP plus ZDV (1week) (moderate certainty).

1 finding from 1 review

An extended ZDV/3TC/LPV/r regimen administered to mothers vs Short‐Course AZT (intrapartum AZT/3TC/sd‐NVP)

Infant Mortality at 6 Months · HIV‐infected mothers and their breastfeeding infants

An extended ZDV/3TC/LPV/r regimen administered to mothers showed no clear difference in infant Mortality at 6 months compared with short course ZDV (intrapartum ZDV/3TC/sdNVP) (low certainty).

1 finding from 1 review

An extended ZDV/3TC/LPV/r regimen administered to mothers vs Short‐Course AZT (intrapartum AZT/3TC/sd‐NVP)

Infant Mortality at 12 months · HIV‐infected mothers and their breastfeeding infants

An extended ZDV/3TC/LPV/r regimen administered to mothers showed no clear difference in infant Mortality at 12 months compared with short course ZDV (intrapartum ZDV/3TC/sdNVP) (low certainty).

1 finding from 1 review

An extended ZDV/3TC/LPV/r regimen administered to mothers vs Short‐Course AZT (intrapartum AZT/3TC/sd‐NVP)

HIV transmission or Death at 6 months among those whose HIV diagnostic testing was negative at 6 weeks after birth · HIV‐infected mothers and their breastfeeding infants

An extended ZDV/3TC/LPV/r regimen administered to mothers showed no clear difference in HIV transmission or Death at 6 months among those whose HIV… compared with short course ZDV (intrapartum ZDV/3TC/sdNVP) (low certainty).

1 finding from 1 review

An extended ZDV/3TC/LPV/r regimen administered to mothers vs Short‐Course AZT (intrapartum AZT/3TC/sd‐NVP)

HIV transmission or death at 12 months among all infants whose HIV diagnostic testing was negative within 6 weeks of birth · HIV‐infected mothers and their breastfeeding infants

An extended ZDV/3TC/LPV/r regimen administered to mothers probably leads to lower HIV transmission or Death at 12 months among those whose HIV… compared with short course ZDV (intrapartum ZDV/3TC/sdNVP) (moderate certainty).

1 finding from 1 review

An extended ZDV/3TC/LPV/r regimen administered to mothers vs Short‐Course AZT (intrapartum AZT/3TC/sd‐NVP)

Maternal Grade 3/4 Severe Adverse Events · HIV‐infected mothers and their breastfeeding infants

It is very uncertain whether an extended ZDV/3TC/LPV/r regimen administered to mothers changes maternal Grade 3/4 Severe Adverse Events compared with short course ZDV (intrapartum ZDV/3TC/sdNVP) (very low certainty).

1 finding from 1 review

An extended antiretroviral regimen administered to mothers for 28 weeks vs 1 week of antiretroviral prophylaxis

HIV transmission at 28 weeks among those whose diagnostic testing was negative at 2 weeks after birth · HIV‐infected mothers and their breastfeeding infants

An extended antiretroviral regimen administered to mothers for 28… probably leads to lower HIV transmission at 28 weeks among those whose diagnostic testing… compared with 1 week of antiretroviral prophylaxis (moderate certainty).

1 finding from 1 review

An extended antiretroviral regimen administered to mothers for 28 weeks vs 1 week of antiretroviral prophylaxis

Infant mortality at 28 weeks among those whose diagnostic testing was negative at 2 weeks after birth · HIV‐infected mothers and their breastfeeding infants

An extended antiretroviral regimen administered to mothers for 28… showed no clear difference in infant mortality at 28 weeks among those whose diagnostic testing… compared with 1 week of antiretroviral prophylaxis (low certainty).

1 finding from 1 review

An extended antiretroviral regimen administered to mothers for 28 weeks vs 1 week of antiretroviral prophylaxis

HIV transmission or death at 28 weeks among those whose diagnostic test was negative at 2 weeks · HIV‐infected mothers and their breastfeeding infants

An extended antiretroviral regimen administered to mothers for 28… probably leads to lower HIV transmission or death at 28 weeks among those whose diagnostic… compared with 1 week of antiretroviral prophylaxis (moderate certainty).

1 finding from 1 review

An extended antiretroviral regimen administered to mothers for 28 weeks vs 1 week of antiretroviral prophylaxis

Infants with Severe Adverse Events · HIV‐infected mothers and their breastfeeding infants

An extended antiretroviral regimen administered to mothers for 28… showed no clear difference in infants with Severe Adverse Events compared with 1 week of antiretroviral prophylaxis (low certainty).

1 finding from 1 review

An extended antiretroviral regimen administered to mothers for 28 weeks vs 1 week of antiretroviral prophylaxis

Mothers with Severe Adverse Events · HIV‐infected mothers and their breastfeeding infants

An extended antiretroviral regimen administered to mothers for 28… may leads to higher mothers with Severe Adverse Events compared with 1 week of antiretroviral prophylaxis (low certainty).

1 finding from 1 review

An extended NVP regimen administered to infants for 14 weeks vs sdNVP plus ZDV (1 week)

HIV Transmission or Death at 24 months among those uninfected at birth · Breastfeeding infants of HIV‐infected mothers

An extended NVP regimen administered to infants for 14 weeks probably leads to lower HIV Transmission or Death at 24 months among those uninfected at… compared with sdNVP plus ZDV (1week) (moderate certainty).

1 finding from 1 review

An extended NVP regimen administered to infants for 28 weeks vs 1 week of antiretroviral prophylaxis

HIV transmission at 28 weeks among those whose diagnostic testing was negative at 2 weeks after birth · Breastfeeding infants of HIV‐infected mothers

An extended NVP regimen administered to infants for 28 weeks may leads to lower HIV transmission at 28 weeks among those whose diagnostic testing… compared with 1 week of antiretroviral prophylaxis (low certainty).

1 finding from 1 review

An extended NVP regimen administered to infants for 28 weeks vs 1 week of antiretroviral prophylaxis

Infant mortality at 28 weeks among those whose diagnostic testing was negative at 2 weeks after birth · Breastfeeding infants of HIV‐infected mothers

An extended NVP regimen administered to infants for 28 weeks showed no clear difference in infant mortality at 28 weeks among those whose diagnostic testing… compared with 1 week of antiretroviral prophylaxis (low certainty).

1 finding from 1 review

An extended NVP regimen administered to infants for 28 weeks vs 1 week of antiretroviral prophylaxis

HIV transmission or death at 28 weeks among those whose diagnostic test was negative at 2 weeks · Breastfeeding infants of HIV‐infected mothers

An extended NVP regimen administered to infants for 28 weeks probably leads to lower HIV transmission or death at 28 weeks among those whose diagnostic… compared with 1 week of antiretroviral prophylaxis (moderate certainty).

1 finding from 1 review

An extended NVP regimen administered to infants for 28 weeks vs 1 week of antiretroviral prophylaxis

Infants with Severe Adverse Events · Breastfeeding infants of HIV‐infected mothers

An extended NVP regimen administered to infants for 28 weeks showed no clear difference in infants with Severe Adverse Events compared with 1 week of antiretroviral prophylaxis (low certainty).

1 finding from 1 review

A once‐daily NVP regimen administered for 6 months vs a once‐daily NVP regimen administered

HIV transmission at 12 months among infants whose HIV diagnostic testing was negative within 6 weeks of birth and whose mothers were not on HAART · Breastfeeding infants of HIV‐infected mothers

A once‐daily NVP regimen administered for 6 months showed no clear difference in HIV transmission at 12 months among infants whose HIV diagnostic… compared with a once‐daily NVP regimen administered (low certainty).

1 finding from 1 review

A once‐daily NVP regimen administered for 6 months vs a once‐daily NVP regimen administered

HIV transmission at 12 months among all infants whose HIV diagnostic testing was negative within 6 weeks of birth · Breastfeeding infants of HIV‐infected mothers

A once‐daily NVP regimen administered for 6 months showed no clear difference in HIV transmission at 12 months among all infants whose HIV diagnostic… compared with a once‐daily NVP regimen administered (low certainty).

1 finding from 1 review

A once‐daily NVP regimen administered for 6 months vs a once‐daily NVP regimen administered

Infant mortality at 12 months among all those whose HIV diagnostic testing was negative within 6 weeks of birth · Breastfeeding infants of HIV‐infected mothers

A once‐daily NVP regimen administered for 6 months showed no clear difference in infant mortality at 12 months among all those whose HIV diagnostic… compared with a once‐daily NVP regimen administered (low certainty).

1 finding from 1 review

A once‐daily NVP regimen administered for 6 months vs a once‐daily NVP regimen administered

HIV transmission or death at 12 months among all infants whose HIV diagnostic testing was negative within 6 weeks of birth · Breastfeeding infants of HIV‐infected mothers

A once‐daily NVP regimen administered for 6 months showed no clear difference in HIV transmission or death at 12 months among all infants whose HIV… compared with a once‐daily NVP regimen administered (moderate certainty).

1 finding from 1 review