Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,092 questions · 3,199 findings · 339 reviews · Headline outcomes only

No studies found 714 · 22.3%GRADE not reported 181 · 5.7%Very low 695 · 21.7%Low 908 · 28.4%Moderate 568 · 17.8%High 133 · 4.2%

Intervention not reported

Proportion of patients who discontinued treatment due to adverse events (28 weeks trial period) · Patients between five and 15 years old with a diagnosis of BECTS

The intervention showed no clear difference in proportion of patients who discontinued treatment due to adverse… (low certainty).

1 finding from 1 review

Intervention not reported

Proportion of patients who are seizure free at 3 months · Patients between three and 10 years old with a diagnosis of BECTS

The intervention probably leads to higher proportion of patients who are seizure free at 3 months (moderate certainty).

1 finding from 1 review

Intervention not reported

Proportion of patients who are seizure free at 6 months · Patients between three and 10 years old with a diagnosis of BECTS

The intervention probably leads to higher proportion of patients who are seizure free at 6 months (moderate certainty).

1 finding from 1 review

Intervention not reported

Proportion of patients who had seizure remission in the last 9 months of the study · Patients with a clinical and EEG diagnosis of BECTS

It is very uncertain whether the intervention changes proportion of patients who had seizure remission in the last 9… (very low certainty).

1 finding from 1 review

Intervention not reported

Proportion of patients who discontinued treatment due to adverse events (96 weeks trial period) · Patients with a clinical and EEG diagnosis of BECTS

It is very uncertain whether the intervention changes proportion of patients who discontinued treatment due to adverse… (very low certainty).

1 finding from 1 review

Intervention not reported

Proportion of patients who are seizure free at 3 months · Patients between three and 12 years old with clinical and EEG diagnosis of BECTS

It is very uncertain whether the intervention changes proportion of patients who are seizure free at 3 months (very low certainty).

1 finding from 1 review

Intervention not reported

Proportion of patients who are seizure free at 12 months · Patients between three and 12 years old with clinical and EEG diagnosis of BECTS

It is very uncertain whether the intervention changes proportion of patients who are seizure free at 12 months (very low certainty).

1 finding from 1 review

Intervention not reported

Proportion of patients who discontinued treatment due to adverse events ( · Patients between three and 12 years old with clinical and EEG diagnosis of BECTS

The intervention showed no clear difference in proportion of patients who discontinued treatment due to adverse… (low certainty).

1 finding from 1 review

Intervention not reported

Low Hb deferral ‐ at first donation visit after commencement of treatment · patients with iron deficiency and/or anaemia in blood donors

The intervention probably leads to lower low Hb deferral ‐ at first donation visit after commencement of… (moderate certainty).

1 finding from 1 review