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Evidence found and GRADE certainty

4,411 questions · 5,986 findings · 226 reviews · Oral Health

No studies found 1,305 · 21.8%GRADE not reported 2,988 · 49.9%Very low 1,030 · 17.2%Low 476 · 8%Moderate 156 · 2.6%High 31 · 0.5%

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Metal-free cantilevered FDPs (feldspathic-veneered zirconia) vs Metal-ceramic cantilevered FDPs

Cantilevered bridge complications · Adults (18 years or older) needing replacement of one premolar or incisor with a cantilevered fixed dental prosthesis

It is very uncertain whether metal-free cantilevered FDPs (feldspathic-veneered zirconia) changes cantilevered bridge complications compared with metal-ceramic cantilevered FDPs (very low certainty).

2 findings from 1 review

Keratinocyte growth factor (KGF; palifermin or repifermin), intravenous vs placebo

Oral mucositis (moderate to severe) · Adults with cancer receiving treatment

Keratinocyte growth factor (KGF; palifermin or repifermin),… may leads to lower oral mucositis (moderate to severe) compared with placebo (low certainty).

3 findings from 1 review

Chinese medicine vs no treatment/placebo

Dry mouth (xerostomia) · Patients receiving radiotherapy on its own or in addition to chemotherapy to the head and neck region

Chinese medicine led to lower xerostomia (dichotomous, Shenqi Fanghou recipe) compared with no treatment/placebo; GRADE not reported.

1 finding from 1 review

Keratinocyte growth factor (KGF; palifermin or repifermin), intravenous vs placebo

Oral pain · Adults with cancer receiving treatment

Keratinocyte growth factor (KGF; palifermin or repifermin),… showed no clear difference in oral pain (mean worst pain, 0 to 10 scale) compared with placebo; GRADE not reported.

2 findings from 1 review

Metal-free implant-supported single crowns (zirconia veneered with feldspathic ceramic) vs Metal-ceramic implant-supported single crowns

Patient satisfaction (measured by patient satisfaction or aesthetic scales) · Adults (18 years or older) with one missing tooth in the aesthetic zone needing an implant-supported single crown

It is very uncertain whether metal-free implant-supported single crowns (zirconia veneered with… changes aesthetic evaluation (patient satisfaction VAS) compared with metal-ceramic implant-supported single crowns (very low certainty).

2 findings from 1 review

Metal-free single crowns (full-contour zirconia) vs Cast gold (conventional metal) single crowns

Crown complications · Adults (18 years or older) needing a single crown in the molar or premolar region

It is very uncertain whether metal-free single crowns (full-contour zirconia) changes crown complications compared with cast gold (conventional metal) single crowns (very low certainty).

2 findings from 1 review

Topical NSAID (ketoprofen lysinate mouthwash, 160 mg) vs Topical NSAID (benzidamine hydrochloride mouthwash, 22.5 mg)

Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · People undergoing orthodontic treatment (any age; 9 to 34 years in included studies)
1 finding from 1 review

Fluoride supplementation (tablets, drops, lozenges or chewing gum) vs placebo or no treatment

Fluorosis (mandibular teeth) at 5 years · Pregnant women (for preventing dental caries in the primary teeth of their children)

It is very uncertain whether fluoride supplementation (tablets, drops, lozenges or chewing gum) changes fluorosis (mandibular teeth) at 5 years compared with placebo or no treatment (very low certainty).

1 finding from 1 review

Amifostine (intravenous) vs Amifostine (subcutaneous)

Adverse effects · Patients receiving radiotherapy on its own or in addition to chemotherapy to the head and neck region
1 finding from 1 review

Resorbable (bioresorbable) plates or screws for fixation vs Titanium plates or screws for fixation

Status of occlusion (e.g. ANB, Angle's classification, Wits analysis) · Adults (>16 years old) undergoing orthognathic surgery
1 finding from 1 review
  • Resorbable versus titanium plates for orthognathic surgery 2017 · Cochrane All outcomes
    Up to 3 years postoperatively
    Weidner 2005 provided analyses of mean changes in ANB from scanned radiographs. The ANB data were incomplete for many of the five time periods and were reported as 'grad' rather than the conventionally accepted…
    1 study · 43 participants
    GRADE not reported

Topical NSAID (ketoprofen chewing gum) vs Local anaesthetic (benzocaine chewing gum)

Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · People undergoing orthodontic treatment (any age; 9 to 34 years in included studies)

It is very uncertain whether topical NSAID (ketoprofen chewing gum) changes pain intensity (VAS 0-100 mm) compared with local anaesthetic (benzocaine chewing gum) (very low certainty).

1 finding from 1 review

Periodontal treatment (scaling and root planing, polishing, or surgery), alone or with oral hygiene counselling, antiseptics, or antimicrobials vs no treatment

Low birth weight < 1500 g · Pregnant women considered to have periodontal disease (gingivitis or periodontitis) after dental examination

It is very uncertain whether periodontal treatment (scaling and root planing, polishing, or… changes low birth weight < 1500 g compared with no treatment (very low certainty).

1 finding from 1 review

Resorbable (bioresorbable) plates or screws for fixation vs Titanium plates or screws for fixation

Need for retreatment or replacement of fixation due to failure of the fixation · Adults (>16 years old) undergoing orthognathic surgery
1 finding from 1 review
  • Resorbable versus titanium plates for orthognathic surgery 2017 · Cochrane All outcomes
    Mean 1 year
    SoF row (Resorbable plates compared to titanium plates for stabilization after orthognathic surgery). Need for retreatment or replacement of fixation due to failure of the fixation (plates failed or removed in each…
    1 study · 60 participants
    Very low

Open surgical exposure vs Closed surgical exposure

Aesthetics: canine rated as abnormal tooth inclination · People with maxillary palatally displaced (impacted) canines, unilateral or bilateral (children/adolescents; mean ages 14.2 to 17.5 years)

Open surgical exposure showed no clear difference in aesthetics: canine rated as abnormal tooth inclination compared with closed surgical exposure; GRADE not reported.

1 finding from 1 review