Adverse effects (other reported events) · Patients receiving radiotherapy on its own or in addition to chemotherapy to the head and neck region
1 finding from 1 review
Alopecia, skin toxicity, hot flush, drowsiness, sneezing, hiccupping, dizziness and fatigue reported narratively or only for the amifostine group; insufficient evidence of a difference
Studies not reported
GRADE not reported
Xerostomia (grade >= 2, 0-4 scale) · Patients receiving radiotherapy on its own or in addition to chemotherapy to the head and neck region
Amifostine may leads to lower xerostomia (grade >= 2, 0-4 scale) compared with no treatment/placebo (low certainty).
3 findings from 1 review
RR 0.35 [0.19, 0.67]
3 studies · 119 participants
Low
RR 0.70 [0.40, 1.23]
7 studies · 682 participants
Low
RR 0.66 [0.48, 0.92]
5 studies · 687 participants
Low
Preterm birth < 32 weeks · Pregnant women considered to have periodontal disease (gingivitis or periodontitis) after dental examination
It is very uncertain whether periodontal treatment (scaling and root planing, polishing, or… changes preterm birth < 32 weeks compared with no treatment (very low certainty).
1 finding from 1 review
Rescue analgesia · People undergoing orthodontic treatment (any age; 9 to 34 years in included studies)
1 finding from 1 review
Allergic adverse events · Patients receiving radiotherapy on its own or in addition to chemotherapy to the head and neck region
Amifostine may leads to higher allergic response (adverse effect) compared with no treatment/placebo (low certainty).
1 finding from 1 review
Re-operation and revision rate / plate removal (adverse effect) · Adults (>16 years old) undergoing orthognathic surgery
1 finding from 1 review
Resorbable versus titanium plates for orthognathic surgery 2017 · Cochrane All outcomesUp to 3 years postoperatively
Plate removal rates were 1.53% (3/196) of the titanium plates and 3.63% (6/165) of the resorbable ones. Out of a total of nine, two in each group were removed because of plate exposure, one patient in the titanium and…
1 study · 60 participants
GRADE not reported
Adverse events · Adults with cancer receiving treatment
1 finding from 1 review
Taste disturbance (severe, > 2 on 0-3 scale) · Patients receiving radiotherapy on its own or in addition to chemotherapy to the head and neck region
Polaprezinc led to lower taste disturbance (severe, > 2 on 0-3 scale) compared with azulene oral rinse; GRADE not reported.
1 finding from 1 review
Quality of life or participant satisfaction · People undergoing orthodontic treatment (any age; 9 to 34 years in included studies)
The review found no eligible studies for this question.
1 finding from 1 review
Adverse effects · Patients receiving radiotherapy on its own or in addition to chemotherapy to the head and neck region
1 finding from 1 review
No evidence of a difference in reported adverse events across the three trials (nausea, fever, constipation, diarrhoea, headache, fatigue and others)
3 studies
GRADE not reported
Abutment failure · Adults (18 years or older) with one missing tooth in the aesthetic zone needing an implant-supported single crown
It is very uncertain whether metal-free implant abutments (zirconia) changes abutment failure compared with metal implant abutments (titanium) (very low certainty).
1 finding from 1 review
Gum health: bleeding on probing (Papilla Bleeding Index) · People with maxillary palatally displaced (impacted) canines, unilateral or bilateral (children/adolescents; mean ages 14.2 to 17.5 years)
Open surgical exposure showed no clear difference in gum health: bleeding on probing (Papilla Bleeding Index) compared with closed surgical exposure; GRADE not reported.
1 finding from 1 review
Decalcification · Participants with full arch fixed orthodontic appliance(s) with molar tubes bonded to first or second permanent molars; excludes prior…
Bonded molar tubes (attached with adhesive) led to higher decalcification (participant level) compared with molar bands (cemented, e.g. with glass ionomer cement); GRADE not reported.
1 finding from 1 review
Normalcy of diet (percutaneous endoscopic gastrostomy) · Adults receiving radiotherapy to the head and neck
Granulocyte-macrophage colony-stimulating factor (GM-CSF), mouthwash showed no clear difference in normalcy of diet (percutaneous endoscopic gastrostomy) compared with sucralfate mouthwash; GRADE not reported.
1 finding from 1 review
Xerostomia (VAS) · Patients receiving radiotherapy on its own or in addition to chemotherapy to the head and neck region
1 finding from 1 review
Oral mucositis (any severity) · Adults with cancer receiving treatment
Granulocyte-colony stimulating factor (G-CSF) led to lower oral mucositis (any severity) compared with placebo or no treatment; GRADE not reported.
2 findings from 1 review
Dry mouth (xerostomia) · Patients receiving radiotherapy on its own or in addition to chemotherapy to the head and neck region
Antimicrobial lozenge showed no clear difference in xerostomia compared with placebo; GRADE not reported.
1 finding from 1 review
Periodontal/peri-implant status (secondary outcomes) · Adults (18 years or older) needing a three-unit fixed dental prosthesis (FDP)
The review found no eligible studies for this question.
1 finding from 1 review
Gum health: gingival recession (six-point probing) · People with maxillary palatally displaced (impacted) canines, unilateral or bilateral (children/adolescents; mean ages 14.2 to 17.5 years)
Open surgical exposure showed no clear difference in gum health: gingival recession (six-point probing) compared with closed surgical exposure; GRADE not reported.
1 finding from 1 review
Patient response: total discomfort score (pain, difficulty eating, brushing, speaking, bad taste) · People with maxillary palatally displaced (impacted) canines, unilateral or bilateral (children/adolescents; mean ages 14.2 to 17.5 years)
Open surgical exposure showed no clear difference in patient response: total discomfort score (pain, difficulty eating,… compared with closed surgical exposure; GRADE not reported.
1 finding from 1 review