Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,678 questions · 4,859 findings · 283 reviews

No studies found 1,225 · 25.2%GRADE not reported 215 · 4.4%Very low 1,241 · 25.5%Low 1,210 · 24.9%Moderate 776 · 16%High 192 · 4%

Summary of findings for NSAIDs plus corticosteroids vs corticosteroids

Intraocular inflammation measured by proportion of participants with corneal edema 1 week · people who received phacoemulsification

Summary of findings for NSAIDs plus corticosteroids showed no clear difference in intraocular inflammation measured by proportion of participants with… compared with corticosteroids alone (moderate certainty).

1 finding from 1 review

Summary of findings ‐ Nipple stimulation (suckling) vs no treatment (comparison 1)

Maternal death · nipple stimulation (suckling) for preventing postpartum haemorrhage in the third stage of labour.

It is very uncertain whether summary of findings ‐ Nipple stimulation (suckling) changes maternal death compared with no treatment (comparison 1) (very low certainty).

1 finding from 1 review

Summary of findings ‐ Nipple stimulation (suckling) vs no treatment (comparison 1)

Frequency of PPH ≥ 500 mL · nipple stimulation (suckling) for preventing postpartum haemorrhage in the third stage of labour.

Summary of findings ‐ Nipple stimulation (suckling) showed no clear difference in frequency of PPH ≥ 500 mL compared with no treatment (comparison 1) (moderate certainty).

1 finding from 1 review

Summary of findings ‐ Nipple stimulation (suckling) vs no treatment (comparison 1)

Retained placenta · nipple stimulation (suckling) for preventing postpartum haemorrhage in the third stage of labour.

It is very uncertain whether summary of findings ‐ Nipple stimulation (suckling) changes retained placenta compared with no treatment (comparison 1) (very low certainty).

1 finding from 1 review

Summary of findings ‐ Nipple stimulation (suckling) vs no treatment (comparison 1)

Perinatal mortality · nipple stimulation (suckling) for preventing postpartum haemorrhage in the third stage of labour.

Summary of findings ‐ Nipple stimulation (suckling) showed no clear difference in perinatal death compared with no treatment (comparison 1) (low certainty).

1 finding from 1 review

Summary of findings ‐ Nipple stimulation (suckling) vs no treatment (comparison 1)

Maternal admission to hospital · nipple stimulation (suckling) for preventing postpartum haemorrhage in the third stage of labour.

It is very uncertain whether summary of findings ‐ Nipple stimulation (suckling) changes maternal admission to hospital compared with no treatment (comparison 1) (very low certainty).

1 finding from 1 review

Antifibrinolytic therapy (tranexamic acid or epsilon aminocaproic acid) vs placebo/open control

All serious adverse events · adults with acute spontaneous intracerebral haemorrhage

Summary of findings table ‐ Antifibrinolytic drug(s) showed no clear difference in all serious adverse events compared with placebo/open control (high certainty).

1 finding from 1 review

Antifibrinolytic therapy (tranexamic acid or epsilon aminocaproic acid) vs placebo/open control

Death from any cause · adults with acute spontaneous intracerebral haemorrhage

Summary of findings table ‐ Antifibrinolytic drug(s) showed no clear difference in death from any cause compared with placebo/open control (high certainty).

1 finding from 1 review

Antifibrinolytic therapy (tranexamic acid or epsilon aminocaproic acid) vs placebo/open control

Death or dependence (mRS 4 to 6) at day 90 · adults with acute spontaneous intracerebral haemorrhage

Summary of findings table ‐ Antifibrinolytic drug(s) showed no clear difference in death or dependence (mRS 4–6) compared with placebo/open control (high certainty).

1 finding from 1 review

Antifibrinolytic therapy (tranexamic acid or epsilon aminocaproic acid) vs placebo/open control

Intracerebral haemorrhage expansion by 24 hours · adults with acute spontaneous intracerebral haemorrhage

Summary of findings table ‐ Antifibrinolytic drug(s) leads to lower intracerebral haemorrhage expansion by 24 hours compared with placebo/open control (high certainty).

1 finding from 1 review