Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

766 questions · 806 findings · 76 reviews · ENT

No studies found 293 · 36.4%GRADE not reported 6 · 0.7%Very low 244 · 30.3%Low 170 · 21.1%Moderate 85 · 10.5%High 8 · 1%

Topical quinolone vs oral amoxicillin‐clavulanic acid combination

Resolution of ear discharge ‐ measured at 1 to 2 weeks · adults with CSOM

It is very uncertain whether topical quinolone changes resolution of ear discharge ‐ 1 to 2 weeks compared with oral amoxicillin‐clavulanic acid combination (very low certainty).

1 finding from 1 review

Anti‐IL‐5 mAb (mepolizumab) vs placebo (on top of topical steroids)

Avoidance of surgery ‐ patients still meeting the criteria for surgery At end of · patients with severe chronic rhinosinusitis with nasal polyps

It is very uncertain whether anti‐IL‐5 mAb (mepolizumab) changes avoidance of surgery ‐ patients still meeting the criteria for… compared with placebo (on top of topical steroids) (very low certainty).

1 finding from 1 review