Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

303 questions · 321 findings · 26 reviews · Gynaecology and Fertility

No studies found 64 · 19.9%GRADE not reported 3 · 0.9%Very low 67 · 20.9%Low 104 · 32.4%Moderate 77 · 24%High 6 · 1.9%

GnRHa treatment vs placebo or no pretreatment

Intraoperative blood loss (mL) · women with uterine fibroids
3 findings from 1 review

GnRHa treatment vs placebo or no pretreatment

Blood transfusion · women with uterine fibroids

GnRHa treatment showed no clear difference in blood transfusions compared with no pretreatment or placebo before myomectomy (operative and… (low certainty).

3 findings from 1 review

GnRHa treatment vs placebo or no pretreatment

Overall postoperative morbidity · women with uterine fibroids

GnRHa treatment showed no clear difference in postoperative morbidity compared with no pretreatment or placebo before myomectomy (operative and… (low certainty).

3 findings from 1 review

SPRM vs placebo

Preoperative bleeding: (PBAC < 75) ulipristal acetate 5 mg · women with uterine fibroids

SPRM may leads to higher preoperative bleeding: (PBAC < 75) ulipristal acetate 5 mg compared with placebo (low certainty).

1 finding from 1 review

SPRM vs placebo

Preoperative bleeding: Reduction in bleeding to PBAC < 75 ulipristal acetate 10 mg · women with uterine fibroids

SPRM may leads to higher preoperative bleeding: Reduction in menstrual bleeding (PBAC < 75)… compared with placebo (low certainty).

1 finding from 1 review

LOD vs other surgical interventions

Harms: Adhesions at 6 months ‐ LOD vs THL N of participants: 246 (1 RCT) · Women with symptoms of PCOS

It is very uncertain whether LOD changes harms: Adhesions at 6 months ‐ LOD vs THL N of participants: 246 (1… compared with other surgical interventions (very low certainty).

1 finding from 1 review

LOD 4‐5 vs 2 or fewer punctures

Menstrual regularity at 12 months Laser LOD vs harmonic scalpel N of participants: 34 (1 RCT) · Women with symptoms of PCOS

LOD 4‐5 may leads to higher menstrual regularity at 6 months ‐ LOD 4 ‐ 5 coagulation points… compared with 2 or fewer punctures (low certainty).

2 findings from 1 review