Findings

What do systematic reviews say?

577 questions · 585 findings · 77 reviews · Cystic Fibrosis and Genetic Disorders

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No studies found 143 · 24.4%GRADE not reported 26 · 4.4%Very low 145 · 24.8%Low 156 · 26.7%Moderate 98 · 16.8%High 17 · 2.9%

Pine bark extract vs placebo

Diastolic blood pressure · adults with CVD

1 finding from 1 review

Pine bark (Pinus spp.) extract for treating chronic disorders 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 61 participants
Very low

Pine bark extract vs placebo

FEV1 % predicted: absolute change from baseline · children and adults with asthma diagnosed by American Thoracic Society criteria

1 finding from 1 review

Pine bark (Pinus spp.) extract for treating chronic disorders 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 44 participants
Very low

Pine bark extract vs placebo

Systolic blood pressure · men with erectile dysfunction

1 finding from 1 review

Pine bark (Pinus spp.) extract for treating chronic disorders 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 111 participants
Very low

Pine bark extract vs placebo

Diastolic blood pressure · men with erectile dysfunction

1 finding from 1 review

Pine bark (Pinus spp.) extract for treating chronic disorders 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 111 participants
Very low

Pine bark extract vs placebo

Change in FEV1 % predicted/FVC · children and adults with asthma diagnosed by American Thoracic Society criteria

1 finding from 1 review

Pine bark (Pinus spp.) extract for treating chronic disorders 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 44 participants
Very low

Summary of findings ‐ Inhaled mannitol vs control (non‐respirable mannitol)

FVC · adults, children and young people with CF

1 finding from 1 review

Inhaled mannitol for cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
1261 participants
Low

Summary of findings ‐ Inhaled mannitol vs control (non‐respirable mannitol)

Lung function: FEF25‐75 mL/s (change from baseline) · adults, children and young people with CF

1 finding from 1 review

Inhaled mannitol for cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
1261 participants
Low

Summary of findings ‐ Inhaled mannitol vs control (non‐respirable mannitol)

FEV1 · children and young adults with CF

The review found no eligible studies for this question.

1 finding from 1 review

Inhaled mannitol for cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings ‐ Inhaled mannitol vs control (non‐respirable mannitol)

FEV1 % predicted: absolute change from baseline · children and young adults with CF

1 finding from 1 review

Inhaled mannitol for cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 22 participants
Low

Summary of findings ‐ Inhaled mannitol vs control (non‐respirable mannitol)

FVC (% predicted) Change from baseline · children and young adults with CF

1 finding from 1 review

Inhaled mannitol for cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 22 participants
Low

Summary of findings ‐ Inhaled mannitol vs control (non‐respirable mannitol)

Lung function: FEF25‐75 mL/s (percentage change from baseline) · children and young adults with CF

1 finding from 1 review

Inhaled mannitol for cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 22 participants
Low

Summary of findings ‐ Inhaled mannitol vs dornase alfa

FEV1 % predicted · children and young adults with CF

The review found no eligible studies for this question.

1 finding from 1 review

Inhaled mannitol for cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings ‐ Inhaled mannitol plus dornase alfa vs dornase alfa

FEV1 % predicted · children and young adults with CF

The review found no eligible studies for this question.

1 finding from 1 review

Inhaled mannitol for cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings ‐ 400 mg inhaled mannitol vs 50 mg inhaled mannitol

FEV1 % predicted: absolute change from baseline · adults, children and young people with CF

1 finding from 1 review

Inhaled mannitol for cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 600 participants
Moderate

Summary of findings ‐ Inhaled mannitol vs control (non‐respirable mannitol)

FEV1 % predicted: absolute change from baseline · adults, children and young people with CF

1 finding from 1 review

Inhaled mannitol for cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
1261 participants
Low

Inhalation before vs during airway clearance techniques

FEV1 % predicted · adults and children with cystic fibrosis

1 finding from 1 review

Timing of hypertonic saline inhalation for cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 63 participants
Low

Inhalation during vs after airway clearance techniques

FEV1 % predicted · adults and children with cystic fibrosis

1 finding from 1 review

Timing of hypertonic saline inhalation for cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 50 participants
Low

Inhalation during vs after airway clearance techniques

FVC · adults and children with cystic fibrosis

1 finding from 1 review

Timing of hypertonic saline inhalation for cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 50 participants
Low

Inhalation before vs during airway clearance techniques

FVC · adults and children with cystic fibrosis

1 finding from 1 review

Timing of hypertonic saline inhalation for cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 50 participants
Low

Inhalation before vs after airway clearance techniques

FEV1 % predicted · adults and children with cystic fibrosis

1 finding from 1 review

Timing of hypertonic saline inhalation for cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 50 participants
Low