Findings

What do systematic reviews say?

603 questions · 627 findings · 69 reviews · Pain, Palliative and Supportive Care

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No studies found 111 · 17.7%GRADE not reported 27 · 4.3%Very low 191 · 30.5%Low 138 · 22%Moderate 100 · 15.9%High 60 · 9.6%

Pregabalin 300 mg vs placebo

Somnolence · adults with moderate or severe pain associated with postherpetic neuralgia

1 finding from 1 review

Pregabalin for neuropathic pain in adults 2019 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 933 participants
Moderate

Pregabalin 300 mg vs placebo

Dizziness · adults with moderate or severe pain associated with postherpetic neuralgia

1 finding from 1 review

Pregabalin for neuropathic pain in adults 2019 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 933 participants
Moderate

Pregabalin 300 mg vs placebo

Withdrawals due to adverse events · adults with moderate or severe pain associated with postherpetic neuralgia

1 finding from 1 review

Pregabalin for neuropathic pain in adults 2019 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 933 participants
High

Pregabalin 600 mg vs placebo

Participant‐reported pain relief of 30% or greater · adults with moderate or severe pain associated with postherpetic neuralgia

1 finding from 1 review

Pregabalin for neuropathic pain in adults 2019 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 537 participants
Moderate

Pregabalin 600 mg vs placebo

Participant‐reported pain relief of 50% or greater · adults with moderate or severe pain associated with postherpetic neuralgia

1 finding from 1 review

Pregabalin for neuropathic pain in adults 2019 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 732 participants
Moderate

Herbal treatment vs placebo

Participant‐reported pain relief of 30% or greater · adults with neuropathic pain

It is very uncertain whether herbal treatment changes participant‐reported pain relief of 30% or greater Immediately… compared with placebo (very low certainty).

1 finding from 1 review

Herbal medicinal products or preparations for neuropathic pain 2019 · Cochrane Headline outcomes only
RR 1.12 [0.69, 1.85]
1 study · 74 participants
Very low

Herbal treatment vs placebo

Participant‐reported pain relief of 50% or greater · adults with neuropathic pain

The review found no eligible studies for this question.

1 finding from 1 review

Herbal medicinal products or preparations for neuropathic pain 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Herbal treatment vs placebo

Patient Global Impression of Change · adults with neuropathic pain

The review found no eligible studies for this question.

1 finding from 1 review

Herbal medicinal products or preparations for neuropathic pain 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Herbal treatment vs placebo

PGIC very much improved · adults with neuropathic pain

The review found no eligible studies for this question.

1 finding from 1 review

Herbal medicinal products or preparations for neuropathic pain 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Herbal treatment vs placebo

Any pain‐related outcome indicating some improvement · adults with neuropathic pain

1 finding from 1 review

Herbal medicinal products or preparations for neuropathic pain 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 74 participants
Very low

Herbal treatment vs placebo

Study withdrawals Post‐intervention · adults with neuropathic pain

It is very uncertain whether herbal treatment changes study withdrawals Post‐intervention compared with placebo (very low certainty).

1 finding from 1 review

Herbal medicinal products or preparations for neuropathic pain 2019 · Cochrane Headline outcomes only
RR 0.83 [0.26, 2.64]
2 studies · 128 participants
Very low

Herbal treatment vs placebo

Adverse events Post‐intervention · adults with neuropathic pain

It is very uncertain whether herbal treatment changes adverse events Post‐intervention compared with placebo (very low certainty).

1 finding from 1 review

Herbal medicinal products or preparations for neuropathic pain 2019 · Cochrane Headline outcomes only
RR 1 [0.55, 1.81]
2 studies · 128 participants
Very low

NSAIDs vs placebo

Participant‐reported pain relief of 50% or greater · adults with sickle cell disease in a vaso‐occlusive crisis

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological interventions for painful sickle cell vaso‐occlusive crises in adults 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Opioids vs placebo

PGIC very much improved · adults with sickle cell disease in a vaso‐occlusive crisis

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological interventions for painful sickle cell vaso‐occlusive crises in adults 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Opioids vs placebo

Patient Global Impression of Change much or very much improved · adults with sickle cell disease in a vaso‐occlusive crisis

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological interventions for painful sickle cell vaso‐occlusive crises in adults 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Opioids vs placebo

Any adverse event · adults with sickle cell disease in a vaso‐occlusive crisis

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological interventions for painful sickle cell vaso‐occlusive crises in adults 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Opioids vs placebo

Serious adverse event · adults with sickle cell disease in a vaso‐occlusive crisis

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological interventions for painful sickle cell vaso‐occlusive crises in adults 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Opioids vs placebo

Withdrawals due to adverse events · adults with sickle cell disease in a vaso‐occlusive crisis

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological interventions for painful sickle cell vaso‐occlusive crises in adults 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

NSAIDs vs placebo

Participant‐reported pain relief of 30% or greater · adults with sickle cell disease in a vaso‐occlusive crisis

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological interventions for painful sickle cell vaso‐occlusive crises in adults 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

NSAIDs vs placebo

PGIC very much improved · adults with sickle cell disease in a vaso‐occlusive crisis

It is very uncertain whether non‐steroidal anti‐inflammatory drugs (NSAID) changes PGIC very much improved ( compared with placebo (very low certainty).

1 finding from 1 review

Pharmacological interventions for painful sickle cell vaso‐occlusive crises in adults 2019 · Cochrane Headline outcomes only
RR 7.64 [0.44, 131.75]
1 study · 21 participants
Very low