Palivizumab vs placebo
- Monoclonal antibody for reducing the risk of respiratory syncytial virus infection in children 2013 · Cochrane Headline outcomes onlyno estimate extracted0 studies · 0 participantsGRADE not reported
PLMA probably leads to lower episodes of hypoxaemia in PACU < 92% oxygen saturation compared with tracheal tube (moderate certainty).
It is very uncertain whether higher changes all‐cause mortality: range 1 mo to 1 y compared with lower FiO2 or targets of arterial oxygenation (very low certainty).
It is very uncertain whether higher changes proportion of participants with ≥ 1 serious adverse events according… compared with lower FiO2 or targets of arterial oxygenation (very low certainty).
It is very uncertain whether higher changes lung injury diagnosed after randomisation (composite outcome): range… compared with lower FiO2 or targets of arterial oxygenation (very low certainty).
It is very uncertain whether higher changes myocardial infarction diagnosed after randomisation: range ≤ 90 d compared with lower FiO2 or targets of arterial oxygenation (very low certainty).
It is very uncertain whether higher changes stroke diagnosed after randomisation: range 1 mo to 3 mo compared with lower FiO2 or targets of arterial oxygenation (very low certainty).
It is very uncertain whether higher changes sepsis diagnosed after randomisation: range 28 d to 60 d compared with lower FiO2 or targets of arterial oxygenation (very low certainty).
Lower showed no clear difference in mortality, near term corrected age or discharge compared with higher oxygen concentrations titrated to target oxygen saturations… (low certainty).
Lower showed no clear difference in neurodevelopmental disability compared with higher oxygen concentrations titrated to target oxygen saturations… (low certainty).
Lower showed no clear difference in intubation in the delivery room compared with higher oxygen concentrations titrated to target oxygen saturations… (low certainty).
Lower showed no clear difference in severe retinopathy of prematurity (≥ stage 3) compared with higher oxygen concentrations titrated to target oxygen saturations… (low certainty).
Lower showed no clear difference in severe intraventricular haemorrhage (grade 3 or 4) compared with higher oxygen concentrations titrated to target oxygen saturations… (low certainty).
Lower showed no clear difference in necrotising enterocolitis compared with higher oxygen concentrations titrated to target oxygen saturations… (low certainty).
It is very uncertain whether lower changes chronic lung disease (36 weeks' corrected age) compared with higher oxygen concentrations titrated to target oxygen saturations… (very low certainty).