Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

369 questions · 377 findings · 28 reviews · Schizophrenia

No studies found 101 · 26.8%GRADE not reported 54 · 14.3%Very low 133 · 35.3%Low 63 · 16.7%Moderate 26 · 6.9%High 0 · 0%

PSYCHOEDUCATIONAL (PE) + MULTIFAMILY TREATMENT (MFT) vs NONSTRUCTURED GROUP THERAPY (NSGT, all long‐term)

Leaving the study early · Adolescents with psychosis

PSYCHOEDUCATIONAL (PE) + MULTIFAMILY TREATMENT (MFT) showed no clear difference in leaving the study early: For any reason compared with NONSTRUCTURED GROUP THERAPY (NSGT, all long‐term) (low certainty).

1 finding from 1 review

ANY INTERMITTENT DRUG TECHNIQUE vs MAINTENANCE THERAPY

Relapse · patients with schizophrenia

ANY INTERMITTENT DRUG TECHNIQUE probably leads to higher relapse: long term (+ 26 weeks) as defined in each study compared with MAINTENANCE THERAPY (moderate certainty).

2 findings from 1 review

INTERMITTENT (EARLY‐BASED) vs MAINTENANCE THERAPY

Adverse effects: tardive dyskinesia: long term (+ 26 weeks) as defined in each study · patients with schizophrenia

INTERMITTENT (EARLY‐BASED) showed no clear difference in adverse effects: tardive dyskinesia: long term (+26 weeks) as… compared with MAINTENANCE THERAPY (low certainty).

1 finding from 1 review

ANY INTERMITTENT DRUG TECHNIQUE vs MAINTENANCE THERAPY

Hospital admissions · patients with schizophrenia

ANY INTERMITTENT DRUG TECHNIQUE probably leads to higher hospitalisation: long term (+ 26 weeks) as defined in each study compared with MAINTENANCE THERAPY (moderate certainty).

2 findings from 1 review