Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

280 questions · 282 findings · 22 reviews · Musculoskeletal

No studies found 87 · 30.9%GRADE not reported 5 · 1.8%Very low 43 · 15.2%Low 94 · 33.3%Moderate 35 · 12.4%High 18 · 6.4%

Intervention not reported

Change in radiographic progression ‐ not measured · patients with treating rheumatoid arthritis

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Achievement of low disease state (DAS 28) ‐ not measured · patients with treating rheumatoid arthritis

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

ACR 50% improvement ( · patients with Rheumatoid arthritis

The intervention showed no clear difference in ACR 50% improvement ( (low certainty).

1 finding from 1 review

Intervention not reported

Change in pain ‐ not measured · patients with Rheumatoid arthritis

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

HAQ disability score ‐ not measured · patients with Rheumatoid arthritis

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Patient reported global impression of clinical change (PGIC) 'good' or 'very good' PGIC scale: Very poor, Poor, No change, Good, Very good. · patients with rheumatoid arthritis pain

The intervention may leads to higher patient reported global impression of clinical change (PGIC) 'good'… (low certainty).

1 finding from 1 review

Intervention not reported

Withdrawal due to inadequate analgesia · patients with rheumatoid arthritis pain

The intervention showed no clear difference in withdrawal due to inadequate analgesia (low certainty).

1 finding from 1 review

Intervention not reported

Functional status (HAQ) HAQ. Scale from: 0 to 3. · patients with rheumatoid arthritis pain
1 finding from 1 review

Intervention not reported

Withdrawal due to adverse events · patients with rheumatoid arthritis pain

The intervention showed no clear difference in withdrawal due to adverse events (low certainty).

1 finding from 1 review

Intervention not reported

Participants reporting adverse events · patients with rheumatoid arthritis pain

The intervention may leads to higher participants reporting adverse events (low certainty).

1 finding from 1 review

Intervention not reported

Pain based on WOMAC pain scale Scale from: 0 (no pain) to 20 (worst pain). ( · patients with treating osteoarthritis
1 finding from 1 review

Intervention not reported

WOMAC Function Subscale Scale from: 0 to 68. ( · patients with treating osteoarthritis
1 finding from 1 review

Intervention not reported

Physician Global Assessment 100 mm visual analogue scale. Scale from: 0 to 100. ( · patients with treating osteoarthritis
1 finding from 1 review

Intervention not reported

Patient Global Assessment (patients rated whether they were better at the end of trial than at the start of the trial) ( · patients with treating osteoarthritis

The intervention showed no clear difference in patient Global Assessment (patients rated whether they were better… (moderate certainty).

1 finding from 1 review

Intervention not reported

Minimum Joint Space Width mm ( · patients with treating osteoarthritis
1 finding from 1 review

Intervention not reported

Toxicity (Number of Patients Reporting Adverse Events) · patients with treating osteoarthritis

The intervention showed no clear difference in toxicity (Number of Patients Reporting Adverse Events) (high certainty).

1 finding from 1 review

Intervention not reported

Toxicity (Number of Withdrawals due to Adverse Events) · patients with treating osteoarthritis

The intervention showed no clear difference in toxicity (Number of Withdrawals due to Adverse Events) (moderate certainty).

1 finding from 1 review

Intervention not reported

Pain based on WOMAC scale Scale from: 0 (no pain) to 20 (worst pain). ( · patients with treating osteoarthritis
1 finding from 1 review

Intervention not reported

WOMAC Function Subscale Scale from: 0 to 68. ( · patients with treating osteoarthritis
1 finding from 1 review