Findings

What do systematic reviews say?

632 questions · 636 findings · 33 reviews · Cystic Fibrosis and Genetic Disorders

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No studies found 197 · 31%GRADE not reported 13 · 2%Very low 133 · 20.9%Low 159 · 25%Moderate 121 · 19%High 13 · 2%

CCPT vs AD

Respiratory exacerbations: number of respiratory exacerbations per year · children and adolescents with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Conventional chest physiotherapy compared to other airway clearance techniques for cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

CCPT vs AD

QoL · children and adolescents with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Conventional chest physiotherapy compared to other airway clearance techniques for cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

CCPT vs AD

Mucus weight · children and adolescents with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Conventional chest physiotherapy compared to other airway clearance techniques for cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

CCPT vs exercise

FEV1 · children and young adults with CF

The review found no eligible studies for this question.

1 finding from 1 review

Conventional chest physiotherapy compared to other airway clearance techniques for cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

CCPT vs exercise

FVC · children and young adults with CF

The review found no eligible studies for this question.

1 finding from 1 review

Conventional chest physiotherapy compared to other airway clearance techniques for cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

CCPT vs exercise

FEF25-75 · children and young adults with CF

The review found no eligible studies for this question.

1 finding from 1 review

Conventional chest physiotherapy compared to other airway clearance techniques for cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

CCPT vs exercise

Respiratory exacerbations: number of respiratory exacerbations per year · children and young adults with CF

The review found no eligible studies for this question.

1 finding from 1 review

Conventional chest physiotherapy compared to other airway clearance techniques for cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

CCPT vs PEP

Respiratory exacerbations: number of respiratory exacerbations per year · adults and children with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Conventional chest physiotherapy compared to other airway clearance techniques for cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

CCPT vs exercise

QoL · children and young adults with CF

The review found no eligible studies for this question.

1 finding from 1 review

Conventional chest physiotherapy compared to other airway clearance techniques for cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

CCPT vs exercise

Mucus weight · children and young adults with CF

The review found no eligible studies for this question.

1 finding from 1 review

Conventional chest physiotherapy compared to other airway clearance techniques for cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

CCPT vs PEP

QoL · adults and children with cystic fibrosis

1 finding from 1 review

Conventional chest physiotherapy compared to other airway clearance techniques for cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 66 participants
Very low

CCPT vs PEP

Mucus weight · adults and children with cystic fibrosis

1 finding from 1 review

Conventional chest physiotherapy compared to other airway clearance techniques for cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 75 participants
Very low

CCPT vs extrapulmonary mechanical percussion

FEV1: rate of decline in FEV1 % predicted · adults and children with cystic fibrosis

1 finding from 1 review

Conventional chest physiotherapy compared to other airway clearance techniques for cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 151 participants
Very low

CCPT vs extrapulmonary mechanical percussion

Annual rate of change in % predicted FVC Subgroup: Under 13 years of age · adults and children with cystic fibrosis

1 finding from 1 review

Conventional chest physiotherapy compared to other airway clearance techniques for cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 151 participants
Very low

Deferasirox vs deferiprone (DFO)

Sustained adherence

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for improving adherence to iron chelation therapy in people with sickle cell disease or thalassaemia 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Deferasirox vs deferiprone (DFO)

QoL

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for improving adherence to iron chelation therapy in people with sickle cell disease or thalassaemia 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings: Comparison 3 ‐ deferiprone (DFP) vs deferasirox (DFX)

Adherence to iron chelation therapy (%, SD)

1 finding from 1 review

Interventions for improving adherence to iron chelation therapy in people with sickle cell disease or thalassaemia 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 390 participants
Low

Summary of findings: Comparison 3 ‐ deferiprone (DFP) vs deferasirox (DFX)

SAE (chelation‐related) (n/N)

1 finding from 1 review

Interventions for improving adherence to iron chelation therapy in people with sickle cell disease or thalassaemia 2023 · Cochrane Headline outcomes only
1.54 [0.44, 5.39]
1 study · 390 participants
Very low

Summary of findings: Comparison 3 ‐ deferiprone (DFP) vs deferasirox (DFX)

SAEs

It is very uncertain whether summary of findings: Comparison 3 ‐ deferiprone (DFP) changes total SAEs compared with deferasirox (DFX) (very low certainty).

1 finding from 1 review

Interventions for improving adherence to iron chelation therapy in people with sickle cell disease or thalassaemia 2023 · Cochrane Headline outcomes only
RR 0.95 [0.46, 1.96]
1 study · 390 participants
Very low

Summary of findings: Comparison 3 ‐ deferiprone (DFP) vs deferasirox (DFX)

All‐cause mortality (n/N)

Summary of findings: Comparison 3 ‐ deferiprone (DFP) showed no clear difference in all‐cause mortality (n/N) compared with deferasirox (DFX) (low certainty).

1 finding from 1 review

Interventions for improving adherence to iron chelation therapy in people with sickle cell disease or thalassaemia 2023 · Cochrane Headline outcomes only
RD 0
1 study · 390 participants
Low