Findings

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Evidence found and GRADE certainty

4,751 questions · 12,775 findings · 807 reviews · Headline outcomes only

No studies found 3,413 · 26.7%GRADE not reported 709 · 5.5%Very low 3,483 · 27.3%Low 3,165 · 24.8%Moderate 1,628 · 12.7%High 377 · 3%

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Intervention not reported

Total studies: 55* Total participants: 3758 No. interventions in network: 21 · adults with malignant pleural effusion Interventions: talc poudrage, bleomycin, IPC – not daily drainage, doxycycline, placebo Comparator…

The intervention led to lower total studies: 55* Total participants: 3758 No. interventions in…; GRADE not reported.

1 finding from 1 review

Intervention not reported

Total studies: 31* Total participants: 2753 No. interventions in network: 14 · adults with malignant pleural effusion Interventions: talc poudrage, bleomycin IPC – not daily drainage, doxycycline, placebo Comparator…

The intervention led to lower total studies: 31* Total participants: 2753 No. interventions in…; GRADE not reported.

1 finding from 1 review

Intervention not reported

Total studies: 31* Total participants: 2816 No. interventions in network: 15 · adults with malignant pleural effusion Interventions: talc poudrage, bleomycin IPC – not daily drainage, doxycycline, placebo Comparator…

The intervention led to lower total studies: 31* Total participants: 2816 No. interventions in…; GRADE not reported.

1 finding from 1 review

Intervention not reported

Total studies: 30 * Total participants: 2004 No. interventions in network: 14 · adults with malignant pleural effusion Interventions: talc poudrage, bleomycin, IPC – not daily drainage, doxycycline, placebo Comparator…

The intervention led to lower total studies: 30 * Total participants: 2004 No. interventions in…; GRADE not reported.

1 finding from 1 review

Lay health worker‐ vs enhanced usual care

Clinical recovery ‐ harmful or dependent alcohol use (1 to 6 months post intervention) Defined by AUDIT score < 8 (RR > 1 denotes higher likelihood of recovery) · adult patients with alcohol dependence

It is very uncertain whether lay health worker‐led interventions changes clinical recovery ‐ harmful or dependent alcohol use (1 to 6 months… compared with enhanced usual care (very low certainty).

1 finding from 1 review

Lay health worker‐ vs enhanced usual care

Clinical symptoms ‐ alcohol use (1 to 6 months post intervention) · adult patients with alcohol dependence

It is very uncertain whether lay health worker‐led interventions changes clinical symptoms ‐ alcohol use (1 to 6 months post intervention) compared with enhanced usual care (very low certainty).

1 finding from 1 review

Lay health worker‐ vs enhanced usual care

Clinical symptoms ‐ depression (1 to 6 months post intervention) · adult patients with alcohol dependence

It is very uncertain whether lay health worker‐led interventions changes clinical symptoms ‐ depression (1 to 6 months post intervention) compared with enhanced usual care (very low certainty).

1 finding from 1 review

Lay health worker‐ vs enhanced usual care

Functional impairment · adult patients with alcohol dependence

It is very uncertain whether lay health worker‐led interventions changes functional impairment (1 to 6 months post intervention) compared with enhanced usual care (very low certainty).

1 finding from 1 review

Lay health worker‐ vs enhanced usual care

Service utilisation ‐ Unplanned hospitalisation in past 12 months (RR > 1 denotes higher risk of hospitalisation) · adult patients with alcohol dependence

It is very uncertain whether lay health worker‐led interventions changes service utilisation ‐ Unplanned hospitalisation in past 12 months… compared with enhanced usual care (very low certainty).

1 finding from 1 review

Lay health worker‐ vs enhanced usual care

Adverse events ‐ death in past 12 months (RR > 1 denotes higher risk of death) · adult patients with alcohol dependence

It is very uncertain whether lay health worker‐led interventions changes adverse events ‐ death in past 12 months (RR > 1 denotes higher risk… compared with enhanced usual care (very low certainty).

1 finding from 1 review

Interventions for involving patients in decision‐making about their health care vs usual care

Psychiatric symptoms Brief Psychiatric Rating Scale (BPRS; Overall 1988): 16 items with 7‐item Likert scale ('not present' to 'extremely severe') measured 6 months after intervention (Yamaguchi 2017). · patients with mental health disorders
1 finding from 1 review

Interventions for involving patients in decision‐making about their health care vs usual care

Depression (6 months or more) MADRS measured 6 months after intervention (Aljumah 2015). PHQ‐9 measured 6 months after intervention (LeBlanc 2015). QIDS‐J measured 6 months after intervention (Aoki 2019a). Hospital Anxiety and Depression Scale (HA... · patients with mental health disorders
1 finding from 1 review

Interventions for involving patients in decision‐making about their health care vs usual care

Patient readmissions · patients with mental health disorders

It is very uncertain whether shared decision‐making interventions changes readmission (6 months or more) Rehospitalisation at 8 months after… compared with usual care (very low certainty).

1 finding from 1 review

Interventions for involving patients in decision‐making about their health care vs usual care

Participation (SDM‐specific‐reported outcomes, immediately after intervention) Combined Outcome Measure for Risk Communication and Treatment Decision‐making Effectiveness (COMRADE; Edwards 2003) measured immediately after decision‐making (Aoki 201... · patients with mental health disorders
1 finding from 1 review