Findings

What do systematic reviews say?

388 questions · 412 findings · 37 reviews · Airways

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No studies found 61 · 14.8%GRADE not reported 42 · 10.2%Very low 68 · 16.5%Low 114 · 27.7%Moderate 100 · 24.3%High 27 · 6.6%

Intervention not reported

HD‐ICS/LABA (Direct evidence; 2 RCTs; 2817 participants) · Adolescents and adults with symptomatic asthma Interventions: HD‐ICS/LABA, MD‐TRIPLE, HD‐TRIPLE Comparator (reference): Medium‐Dose…

1 finding from 1 review

Effectiveness and tolerability of dual and triple combination inhaler therapies compared with each other and varying… 2022 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 2817 participants
Moderate

Intervention not reported

MD‐TRIPLE (Direct evidence; 2 RCTs; 2237 participants) · Adolescents and adults with symptomatic asthma Interventions: HD‐ICS/LABA, MD‐TRIPLE, HD‐TRIPLE Comparator (reference): Medium‐Dose…

1 finding from 1 review

Effectiveness and tolerability of dual and triple combination inhaler therapies compared with each other and varying… 2022 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 2237 participants
Moderate

Intervention not reported

HD‐TRIPLE (Direct evidence; 1 RCT; 1088 participants) · Adolescents and adults with symptomatic asthma Interventions: HD‐ICS/LABA, MD‐TRIPLE, HD‐TRIPLE Comparator (reference): Medium‐Dose…

1 finding from 1 review

Effectiveness and tolerability of dual and triple combination inhaler therapies compared with each other and varying… 2022 · Cochrane Headline outcomes only
no estimate extracted
1 study · 1088 participants
Moderate

Intervention not reported

MD‐ICS/LABA · Adolescents and adults with symptomatic asthma Interventions: HD‐ICS/LABA, MD‐TRIPLE, HD‐TRIPLE Comparator (reference): Medium‐Dose…

The review found no eligible studies for this question.

1 finding from 1 review

Effectiveness and tolerability of dual and triple combination inhaler therapies compared with each other and varying… 2022 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Macrolides vs no intervention

All‐cause mortality · adults with bronchiectasis

1 finding from 1 review

Macrolide antibiotics for bronchiectasis 2018 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 88 participants
Very low

Macrolides vs no intervention

SGRQ Total SGRQ (Total) Score. Scale from: 0 to 100. Lower score indicates better quality of life. · adults with bronchiectasis

1 finding from 1 review

Macrolide antibiotics for bronchiectasis 2018 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 89 participants
Moderate

Macrolides vs no intervention

Change in SGRQ total score · adults with bronchiectasis

1 finding from 1 review

Macrolide antibiotics for bronchiectasis 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 30 participants
Moderate

Macrolides vs no intervention

Exacerbations ‐ not reported · children with bronchiectasis

The review found no eligible studies for this question.

1 finding from 1 review

Macrolide antibiotics for bronchiectasis 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Macrolides vs no intervention

Hospitalisation ‐ not reported · children with bronchiectasis

The review found no eligible studies for this question.

1 finding from 1 review

Macrolide antibiotics for bronchiectasis 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Macrolides vs no intervention

Serious adverse events ‐ not reported · children with bronchiectasis

The review found no eligible studies for this question.

1 finding from 1 review

Macrolide antibiotics for bronchiectasis 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Macrolides vs no intervention

All‐cause mortality · children with bronchiectasis

1 finding from 1 review

Macrolide antibiotics for bronchiectasis 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 34 participants
Low

Macrolides vs no intervention

Quality of life ‐ not reported · children with bronchiectasis

The review found no eligible studies for this question.

1 finding from 1 review

Macrolide antibiotics for bronchiectasis 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Macrolides vs no intervention

Exacerbations (number of people experiencing ≥ 1 exacerbations) · adults with bronchiectasis

Macrolides showed no clear difference in ≥ 1 exacerbation compared with no intervention (moderate certainty).

1 finding from 1 review

Macrolide antibiotics for bronchiectasis 2018 · Cochrane Headline outcomes only
OR 0.31 [0.08, 1.15]
1 study · 43 participants
Moderate

Macrolides vs no intervention

Hospitalisation ‐ not reported · adults with bronchiectasis

The review found no eligible studies for this question.

1 finding from 1 review

Macrolide antibiotics for bronchiectasis 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Macrolides vs no intervention

Serious adverse events ‐ not reported · adults with bronchiectasis

The review found no eligible studies for this question.

1 finding from 1 review

Macrolide antibiotics for bronchiectasis 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

Proportion of people with COPD diagnoses confirmed with spirometry · health professionals managing COPD

1 finding from 1 review

Educational interventions for health professionals managing chronic obstructive pulmonary disease in primary care 2022 · Cochrane Headline outcomes only
no estimate extracted
4 participants
Very low

Intervention not reported

Proportion of patients with COPD referred to, participating in or having completed pulmonary rehabilitation · health professionals managing COPD

1 finding from 1 review

Educational interventions for health professionals managing chronic obstructive pulmonary disease in primary care 2022 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 625 participants
Low

Intervention not reported

Proportion of patients with COPD prescribed respiratory medication consistent with recommended guidelines · health professionals managing COPD

1 finding from 1 review

Educational interventions for health professionals managing chronic obstructive pulmonary disease in primary care 2022 · Cochrane Headline outcomes only
no estimate extracted
12 studies · 52899 participants
Low

Intervention not reported

Proportion of patients with COPD vaccinated against influenza/pneumococcal infections · health professionals managing COPD

1 finding from 1 review

Educational interventions for health professionals managing chronic obstructive pulmonary disease in primary care 2022 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 6846 participants
Moderate

Intervention not reported

HRQoL · health professionals managing COPD

1 finding from 1 review

Educational interventions for health professionals managing chronic obstructive pulmonary disease in primary care 2022 · Cochrane Headline outcomes only
no estimate extracted
12 studies · 6526 participants
Low