Findings

What do systematic reviews say?

275 questions · 608 findings · 35 reviews

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No studies found 1 · 0.2%GRADE not reported 590 · 97%Very low 0 · 0%Low 5 · 0.8%Moderate 5 · 0.8%High 7 · 1.2%

Lower family socioeconomic status / income vs Higher socioeconomic position

Periodontitis and allostatic load · US adults in NHANES 1999-2004

Allostatic load increased the probability of periodontitis and the association varied by race/ethnicity.

1 finding from 1 review

Social-Biological Interactions in Oral Disease: A 'Cells to Society' View. 2016 All outcomes
United States · Race/ethnicity
no estimate extracted
1 study
GRADE not reported

Low socioeconomic status and family financial stress vs Higher socioeconomic status and lower stress

Salivary cortisol, cariogenic bacterial load and dental caries · Kindergarten-age children

In one cross-sectional study of children, low socioeconomic status, higher basal salivary cortisol and higher cariogenic bacterial counts were each independently associated with higher dental caries risk; not pooled (ungraded).

1 finding from 1 review

Social-Biological Interactions in Oral Disease: A 'Cells to Society' View. 2016 All outcomes
Kindergarten children, California, USA (Peers and Wellness Study)
no estimate extracted
1 study · 94 participants
GRADE not reported

Low socioeconomic position and adverse behavioural factors vs Higher socioeconomic position and fewer adverse behaviours

Systemic inflammation (C-reactive protein) and periodontal disease progression · General-population adults (German cohort)

In one 5-year longitudinal study, accumulation of low socioeconomic and behavioural factors was associated with greater periodontal disease progression and higher C-reactive protein; not pooled (ungraded).

1 finding from 1 review

Social-Biological Interactions in Oral Disease: A 'Cells to Society' View. 2016 All outcomes
5-year follow-up · General adult population, Germany (Study of Health in Pomerania)
no estimate extracted
1 study · 3300 participants
GRADE not reported

11-16 remaining teeth vs 25-32 remaining teeth

Atherosclerotic cardiovascular disease (ACVD)-related events (morbidity and mortality) · Adults (any age) with a known number of remaining teeth, followed prospectively in cohort studies

In prospective cohorts, adults with 11-16 teeth had a higher cumulative incidence of ACVD-related events than adults with 25-32 teeth (RR 2.27, 95% CI 1.55 to 3.32; 4 cohort studies, I2=87%); GRADE per-analysis ratings reported in Supplementary File 7 (not available in provided sources).

1 finding from 1 review

Lower Number of Teeth Is Related to Higher Risks for ACVD and Death-Systematic Review and Meta-Analyses of Survival… 2021 All outcomes
Community-based and clinical cohorts worldwide (all continents); events ascertained from medical records, death certificates/registers, or self-report
RR 2.27 [1.55, 3.32]
4 studies · 189120 participants
High

Edentulous (0 remaining teeth) vs 1-32 remaining teeth

All-cause mortality (ACM) · Adults (any age) with a known number of remaining teeth, followed prospectively in cohort studies

In prospective cohorts, the multivariable-adjusted HR for all-cause mortality in edentulous adults (0 teeth) vs adults with 1-32 teeth was 1.30 (95% CI 1.21 to 1.40; 7 studies, I2=20%); GRADE per-analysis ratings reported in Supplementary File 7 (not available in provided sources).

4 findings from 1 review

Lower Number of Teeth Is Related to Higher Risks for ACVD and Death-Systematic Review and Meta-Analyses of Survival… 2021 All outcomes
Community-based and clinical cohorts worldwide (all continents); events ascertained from medical records, death certificates/registers, or self-report · Multivariable-adjusted
HR 1.30 [1.21, 1.40]
7 studies · 102254 participants
Moderate
Lower Number of Teeth Is Related to Higher Risks for ACVD and Death-Systematic Review and Meta-Analyses of Survival… 2021 All outcomes
Community-based and clinical cohorts worldwide (all continents); events ascertained from medical records, death certificates/registers, or self-report · Adjusted for age/sex
HR 1.56 [1.48, 1.65]
3 studies · 43734 participants
GRADE not reported
Lower Number of Teeth Is Related to Higher Risks for ACVD and Death-Systematic Review and Meta-Analyses of Survival… 2021 All outcomes
Community-based and clinical cohorts worldwide (all continents); events ascertained from medical records, death certificates/registers, or self-report
RR 1.94 [1.19, 3.15]
14 studies · 4711667 participants
Low

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Lower Number of Teeth Is Related to Higher Risks for ACVD and Death-Systematic Review and Meta-Analyses of Survival… 2021 All outcomes
Community-based and clinical cohorts worldwide (all continents); events ascertained from medical records, death certificates/registers, or self-report · Crude
HR 1.73 [1.41, 2.13]
5 studies · 99303 participants
GRADE not reported

17-24 remaining teeth vs 25-32 remaining teeth

Atherosclerotic cardiovascular disease (ACVD)-related events (morbidity and mortality) · Adults (any age) with a known number of remaining teeth, followed prospectively in cohort studies

In prospective cohorts, adults with 17-24 teeth had a higher cumulative incidence of ACVD-related events than adults with 25-32 teeth (RR 1.73, 95% CI 1.22 to 2.45; 4 cohort studies, I2=87%); GRADE per-analysis ratings reported in Supplementary File 7 (not available in provided sources).

1 finding from 1 review

Lower Number of Teeth Is Related to Higher Risks for ACVD and Death-Systematic Review and Meta-Analyses of Survival… 2021 All outcomes
Community-based and clinical cohorts worldwide (all continents); events ascertained from medical records, death certificates/registers, or self-report
RR 1.73 [1.22, 2.45]
4 studies · 213202 participants
High

0-19 remaining teeth vs 20-32 remaining teeth

All-cause mortality (ACM) · Adults (any age) with a known number of remaining teeth, followed prospectively in cohort studies

In prospective cohorts, the crude HR for all-cause mortality in adults with 0-19 teeth vs adults with 20-32 teeth was 2.47 (95% CI 2.40 to 2.54; 2 studies, I2=0%); GRADE per-analysis ratings reported in Supplementary File 7 (not available in provided sources).

4 findings from 1 review

Lower Number of Teeth Is Related to Higher Risks for ACVD and Death-Systematic Review and Meta-Analyses of Survival… 2021 All outcomes
Community-based and clinical cohorts worldwide (all continents); events ascertained from medical records, death certificates/registers, or self-report · Crude
HR 2.47 [2.40, 2.54]
2 studies · 36379 participants
GRADE not reported
Lower Number of Teeth Is Related to Higher Risks for ACVD and Death-Systematic Review and Meta-Analyses of Survival… 2021 All outcomes
Community-based and clinical cohorts worldwide (all continents); events ascertained from medical records, death certificates/registers, or self-report
RR 1.84 [1.52, 2.23]
11 studies · 267575 participants
Low
Lower Number of Teeth Is Related to Higher Risks for ACVD and Death-Systematic Review and Meta-Analyses of Survival… 2021 All outcomes
Community-based and clinical cohorts worldwide (all continents); events ascertained from medical records, death certificates/registers, or self-report · Multivariable-adjusted
HR 1.29 [1.21, 1.37]
10 studies · 305970 participants
Low

Show 1 more finding

Lower Number of Teeth Is Related to Higher Risks for ACVD and Death-Systematic Review and Meta-Analyses of Survival… 2021 All outcomes
Community-based and clinical cohorts worldwide (all continents); events ascertained from medical records, death certificates/registers, or self-report · Adjusted for age/sex
HR 1.42 [1.15, 1.75]
5 studies · 212657 participants
GRADE not reported

1-19 remaining teeth vs 20-32 remaining teeth

All-cause mortality (ACM) · Adults (any age) with a known number of remaining teeth, followed prospectively in cohort studies

In prospective cohorts, adults with 1-19 teeth had a higher cumulative incidence of all-cause mortality than adults with 20-32 teeth (RR 1.76, 95% CI 1.41 to 2.19; 8 cohort studies, I2=94%); GRADE per-analysis ratings reported in Supplementary File 7 (not available in provided sources).

1 finding from 1 review

Lower Number of Teeth Is Related to Higher Risks for ACVD and Death-Systematic Review and Meta-Analyses of Survival… 2021 All outcomes
Community-based and clinical cohorts worldwide (all continents); events ascertained from medical records, death certificates/registers, or self-report
RR 1.76 [1.41, 2.19]
8 studies · 222572 participants
High

Edentulous (0 remaining teeth) vs 1-32 remaining teeth

Atherosclerotic cardiovascular disease (ACVD)-related events (morbidity and mortality) · Adults (any age) with a known number of remaining teeth, followed prospectively in cohort studies

In prospective cohorts, the multivariable-adjusted HR for ACVD-related events in edentulous adults (0 teeth) vs adults with 1-32 teeth was 1.21 (95% CI 1.07 to 1.36; 5 studies, I2=35%); GRADE per-analysis ratings reported in Supplementary File 7 (not available in provided sources).

4 findings from 1 review

Lower Number of Teeth Is Related to Higher Risks for ACVD and Death-Systematic Review and Meta-Analyses of Survival… 2021 All outcomes
Community-based and clinical cohorts worldwide (all continents); events ascertained from medical records, death certificates/registers, or self-report · Multivariable-adjusted
HR 1.21 [1.07, 1.36]
5 studies · 101938 participants
Moderate
Lower Number of Teeth Is Related to Higher Risks for ACVD and Death-Systematic Review and Meta-Analyses of Survival… 2021 All outcomes
Community-based and clinical cohorts worldwide (all continents); events ascertained from medical records, death certificates/registers, or self-report · Crude
HR 1.89 [1.80, 1.99]
3 studies · 98122 participants
GRADE not reported
Lower Number of Teeth Is Related to Higher Risks for ACVD and Death-Systematic Review and Meta-Analyses of Survival… 2021 All outcomes
Community-based and clinical cohorts worldwide (all continents); events ascertained from medical records, death certificates/registers, or self-report
RR 2.93 [1.92, 4.50]
10 studies · 4697021 participants
Moderate

Show 1 more finding

Lower Number of Teeth Is Related to Higher Risks for ACVD and Death-Systematic Review and Meta-Analyses of Survival… 2021 All outcomes
Community-based and clinical cohorts worldwide (all continents); events ascertained from medical records, death certificates/registers, or self-report · Adjusted for age/sex
HR 1.49 [1.39, 1.58]
4 studies · 44937 participants
GRADE not reported

0-19 remaining teeth vs 20-32 remaining teeth

Atherosclerotic cardiovascular disease (ACVD)-related events (morbidity and mortality) · Adults (any age) with a known number of remaining teeth, followed prospectively in cohort studies

In prospective cohorts, the crude HR for ACVD-related events in adults with 0-19 teeth vs adults with 20-32 teeth was 2.27 (95% CI 1.50 to 3.43; 1 study, I2 not applicable (single study)); GRADE per-analysis ratings reported in Supplementary File 7 (not available in provided sources).

4 findings from 1 review

Lower Number of Teeth Is Related to Higher Risks for ACVD and Death-Systematic Review and Meta-Analyses of Survival… 2021 All outcomes
Community-based and clinical cohorts worldwide (all continents); events ascertained from medical records, death certificates/registers, or self-report · Crude
HR 2.27 [1.50, 3.43]
1 study · 4380 participants
GRADE not reported
Lower Number of Teeth Is Related to Higher Risks for ACVD and Death-Systematic Review and Meta-Analyses of Survival… 2021 All outcomes
Community-based and clinical cohorts worldwide (all continents); events ascertained from medical records, death certificates/registers, or self-report · Adjusted for age/sex
HR 1.29 [1.08, 1.53]
3 studies · 186749 participants
GRADE not reported
Lower Number of Teeth Is Related to Higher Risks for ACVD and Death-Systematic Review and Meta-Analyses of Survival… 2021 All outcomes
Community-based and clinical cohorts worldwide (all continents); events ascertained from medical records, death certificates/registers, or self-report
RR 1.98 [1.86, 2.10]
4 studies · 191129 participants
Moderate

Show 1 more finding

Lower Number of Teeth Is Related to Higher Risks for ACVD and Death-Systematic Review and Meta-Analyses of Survival… 2021 All outcomes
Community-based and clinical cohorts worldwide (all continents); events ascertained from medical records, death certificates/registers, or self-report · Multivariable-adjusted
HR 1.19 [1.13, 1.26]
4 studies · 191129 participants
Moderate

Edentulous (0 remaining teeth) vs 20-32 remaining teeth

Atherosclerotic cardiovascular disease (ACVD)-related events (morbidity and mortality) · Adults (any age) with a known number of remaining teeth, followed prospectively in cohort studies

In prospective cohorts, edentulous adults (0 teeth) had a higher cumulative incidence of ACVD-related events than adults with 20-32 teeth (RR 2.65, 95% CI 1.77 to 3.98; 2 cohort studies, I2=60%); GRADE per-analysis ratings reported in Supplementary File 7 (not available in provided sources).

1 finding from 1 review

Lower Number of Teeth Is Related to Higher Risks for ACVD and Death-Systematic Review and Meta-Analyses of Survival… 2021 All outcomes
Community-based and clinical cohorts worldwide (all continents); events ascertained from medical records, death certificates/registers, or self-report
RR 2.65 [1.77, 3.98]
2 studies · 130669 participants
High

1-19 remaining teeth vs 20-32 remaining teeth

Atherosclerotic cardiovascular disease (ACVD)-related events (morbidity and mortality) · Adults (any age) with a known number of remaining teeth, followed prospectively in cohort studies

In prospective cohorts, adults with 1-19 teeth had a higher cumulative incidence of ACVD-related events than adults with 20-32 teeth (RR 1.69, 95% CI 1.13 to 2.53; 2 cohort studies, I2=60%); GRADE per-analysis ratings reported in Supplementary File 7 (not available in provided sources).

1 finding from 1 review

Lower Number of Teeth Is Related to Higher Risks for ACVD and Death-Systematic Review and Meta-Analyses of Survival… 2021 All outcomes
Community-based and clinical cohorts worldwide (all continents); events ascertained from medical records, death certificates/registers, or self-report
RR 1.69 [1.13, 2.53]
2 studies · 165066 participants
High

Edentulous (0 remaining teeth) vs 20-32 remaining teeth

All-cause mortality (ACM) · Adults (any age) with a known number of remaining teeth, followed prospectively in cohort studies

In prospective cohorts, edentulous adults (0 teeth) had a higher cumulative incidence of all-cause mortality than adults with 20-32 teeth (RR 2.27, 95% CI 1.82 to 2.83; 8 cohort studies, I2=94%); GRADE per-analysis ratings reported in Supplementary File 7 (not available in provided sources).

1 finding from 1 review

Lower Number of Teeth Is Related to Higher Risks for ACVD and Death-Systematic Review and Meta-Analyses of Survival… 2021 All outcomes
Community-based and clinical cohorts worldwide (all continents); events ascertained from medical records, death certificates/registers, or self-report
RR 2.27 [1.82, 2.83]
8 studies · 180222 participants
High

0-10 remaining teeth vs 25-32 remaining teeth

Atherosclerotic cardiovascular disease (ACVD)-related events (morbidity and mortality) · Adults (any age) with a known number of remaining teeth, followed prospectively in cohort studies

In prospective cohorts, adults with 0-10 teeth had a higher cumulative incidence of ACVD-related events than adults with 25-32 teeth (RR 2.65, 95% CI 1.84 to 3.81; 4 cohort studies, I2=87%); GRADE per-analysis ratings reported in Supplementary File 7 (not available in provided sources).

1 finding from 1 review

Lower Number of Teeth Is Related to Higher Risks for ACVD and Death-Systematic Review and Meta-Analyses of Survival… 2021 All outcomes
Community-based and clinical cohorts worldwide (all continents); events ascertained from medical records, death certificates/registers, or self-report
RR 2.65 [1.84, 3.81]
4 studies · 193546 participants
High

Intervention not reported

Development of carious lesions on sealed occlusal pits and fissures

The intervention led to lower development of carious lesions on sealed occlusal pits and fissures; GRADE not reported.

1 finding from 1 review

Caries-Preventive Effect of High-Viscosity Glass Ionomer and Resin-Based Fissure Sealants on Permanent Teeth: A… 2016 All outcomes
60 months
RD -0.07 [-0.14, -0.01]
2 studies
GRADE not reported