Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

469 questions · 483 findings · 63 reviews

No studies found 117 · 24.2%GRADE not reported 13 · 2.7%Very low 68 · 14.1%Low 141 · 29.2%Moderate 112 · 23.2%High 32 · 6.6%

Antioxidants vs placebo

Reduction of TTM symptom severityMassachusetts General Hospital Hair‐Pulling Scale (MGH‐HPS) · adults with trichotillomania
1 finding from 1 review

Antioxidants vs placebo

Reduction of TTM symptom severityMassachusetts General Hospital Hair‐Pulling Scale (MGH‐HPS) · children with trichotillomania
1 finding from 1 review

Sulthiame vs levetiracetam

Adverse effects (general symptoms) · participants with epilepsy (BECTS)

Sulthiame showed no clear difference in adverse effects (general symptoms) compared with levetiracetam (low certainty).

1 finding from 1 review

Carboplatin vs cisplatin chemotherapy

Overall survival (baseline risks for low‐ and high‐risk groups in the control arm were estimated at 1 year) · combination with third‐generation drugs for advanced non‐small cell lung cancer

Carboplatin showed no clear difference in overall survival (baseline risks for low‐ and high‐risk groups in… compared with cisplatin chemotherapy (high certainty).

1 finding from 1 review

Carboplatin vs cisplatin chemotherapy

Adverse events: neurotoxicity (grade 3/4) ( · combination with third‐generation drugs for advanced non‐small cell lung cancer

Carboplatin probably leads to higher grade III or IV neurotoxicity compared with cisplatin chemotherapy (moderate certainty).

1 finding from 1 review

Carboplatin vs cisplatin chemotherapy

Safety (AE, adverse drug reaction): thrombocytopenia Grades 3 or 4 according to National Cancer Institute · combination with third‐generation drugs for advanced non‐small cell lung cancer

Carboplatin probably leads to higher grade III or IV thrombocytopenia compared with cisplatin chemotherapy (moderate certainty).

1 finding from 1 review

Carboplatin vs cisplatin chemotherapy

Grade III or IV renal toxicity · combination with third‐generation drugs for advanced non‐small cell lung cancer

Carboplatin showed no clear difference in grade III or IV renal toxicity compared with cisplatin chemotherapy (moderate certainty).

1 finding from 1 review