Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

285 questions · 290 findings · 75 reviews · Headline outcomes only

No studies found 81 · 27.9%GRADE not reported 18 · 6.2%Very low 91 · 31.4%Low 62 · 21.4%Moderate 32 · 11%High 6 · 2.1%

Antibiotics vs control

Active trachoma · people (any age) with active trachoma

Antibiotic may leads to lower active trachoma Clinical assessment: active trachoma defined as TF,… compared with control (low certainty).

1 finding from 1 review

Oral azithromycin vs control

Ocular chlamydia trachomatis infection · people (any age) with active trachoma

The review found no eligible studies for this question.

1 finding from 1 review
  • Antibiotics for trachoma 2019 · Cochrane Headline outcomes only
    no estimate extracted
    Studies not reported
    No studies found

Oral azithromycin vs control

Antibiotic resistance · people (any age) with active trachoma

Oral azithromycin led to lower antibiotic resistance Proportion of samples showing evidence of… compared with control; GRADE not reported.

1 finding from 1 review
  • Antibiotics for trachoma 2019 · Cochrane Headline outcomes only
    no estimate extracted
    4 studies · 1354 participants
    GRADE not reported

Antibiotics vs control

Ocular chlamydia trachomatis infection · people (any age) with active trachoma

Antibiotic showed no clear difference in ocular C trachomatis infection Positive test for C trachomatis… compared with control (low certainty).

1 finding from 1 review

Antibiotics vs control

Antibiotic resistance · people (any age) with active trachoma

The review found no eligible studies for this question.

1 finding from 1 review
  • Antibiotics for trachoma 2019 · Cochrane Headline outcomes only
    no estimate extracted
    Studies not reported
    No studies found

Antibiotics vs control

Adverse effects · people (any age) with active trachoma

Antibiotic may leads to lower adverse effects compared with control (low certainty).

1 finding from 1 review

Oral vs topical antibiotics

Active trachoma · people (any age) with active trachoma

Oral showed no clear difference in active trachoma Clinical assessment: active trachoma defined as TF,… compared with topical antibiotic (low certainty).

1 finding from 1 review

Oral vs topical antibiotics

Antibiotic resistance · people (any age) with active trachoma

The review found no eligible studies for this question.

1 finding from 1 review
  • Antibiotics for trachoma 2019 · Cochrane Headline outcomes only
    no estimate extracted
    Studies not reported
    No studies found

Oral azithromycin vs control

Active trachoma · people (any age) with active trachoma

The review found no eligible studies for this question.

1 finding from 1 review
  • Antibiotics for trachoma 2019 · Cochrane Headline outcomes only
    no estimate extracted
    Studies not reported
    No studies found

Intervention not reported

Aggression OAS, OAS‐M, MOAS, self‐reported incidents, CPRS subscale (endpoints fall between 2 weeks and 6 months) · Any individual experiencing recurrent aggressive outbursts or episodes
1 finding from 1 review