Mean time to resolution of pain · Adults (>18 years) with established dry socket following permanent tooth extraction
Neocone led to lower time to complete resolution of pain (days) compared with zinc oxide eugenol; GRADE not reported.
1 finding from 1 review
MRONJ (incidence proportion) · Men with metastatic prostate cancer receiving intravenous zoledronic acid (at risk of MRONJ)
It is very uncertain whether dental examinations at three-month intervals and preventive treatments changes MRONJ (incidence proportion) compared with standard care (very low certainty).
1 finding from 1 review
Presence of dry socket · Adults (>18 years) having permanent tooth extraction (predominantly mandibular third molars)
Metronidazole gel (25%, intrasocket) showed no clear difference in presence of dry socket compared with placebo gel; GRADE not reported.
1 finding from 1 review
Self‐reported shoulder function: Croft Shoulder Disability Score (1 or more problems) · adults with minimally displaced or displaced (2‐part or 3‐part) proximal humeral fractures treated non‐surgically (5 trials)
It is very uncertain whether early changes self‐reported shoulder function: Croft Shoulder Disability Score (1… compared with delayed mobilisation (very low certainty).
2 findings from 1 review
Functional outcomes · (mainly older) adults with most types of displaced proximal humeral fracturesa (10 trials)
Surgical showed no clear difference in functional scoresf(higher = better outcome) compared with non‐surgical treatment (high certainty).
3 findings from 1 review
SMD 0.06
5 studies · 423 participants
High
SMD 0.1
7 studies · 552 participants
High
SMD 0.17
3 studies · 347 participants
Moderate
Quality of life: EQ‐5D (0: dead to 1: best quality of life) · (mainly older) adults with most types of displaced proximal humeral fracturesa (10 trials)
Surgical showed no clear difference in quality of life: EQ‐5D (0: dead to 1: best quality of life) compared with non‐surgical treatment (high certainty).
1 finding from 1 review
All‐cause mortality · (mainly older) adults with most types of displaced proximal humeral fracturesa (10 trials)
Surgical showed no clear difference in mortality compared with non‐surgical treatment (low certainty).
1 finding from 1 review
Reoperation · (mainly older) adults with most types of displaced proximal humeral fracturesa (10 trials)
Surgical may leads to higher additional surgery (reoperation or secondary surgery) compared with non‐surgical treatment (low certainty).
1 finding from 1 review
Adverse events / complications ‐ Number of participants with complications · (mainly older) adults with most types of displaced proximal humeral fracturesa (10 trials)
Surgical showed no clear difference in adverse events / complications ‐ Number of participants with… compared with non‐surgical treatment (low certainty).
1 finding from 1 review
Self‐reported shoulder function · adults with minimally displaced or displaced (2‐part or 3‐part) proximal humeral fractures treated non‐surgically (5 trials)
1 finding from 1 review
Quality of life: EQ‐5D (0: dead to 1: best quality of life) · adults with minimally displaced or displaced (2‐part or 3‐part) proximal humeral fractures treated non‐surgically (5 trials)
1 finding from 1 review
All‐cause mortality · adults with minimally displaced or displaced (2‐part or 3‐part) proximal humeral fractures treated non‐surgically (5 trials)
1 finding from 1 review
Adverse events: Shoulder complications · adults with minimally displaced or displaced (2‐part or 3‐part) proximal humeral fractures treated non‐surgically (5 trials)
1 finding from 1 review
Additional surgery or substantive treatment · adults with minimally displaced or displaced (2‐part or 3‐part) proximal humeral fractures treated non‐surgically (5 trials)
1 finding from 1 review
Complete remission · minimal change disease in adults with nephrotic syndrome
It is very uncertain whether steroids changes complete remission Time frame: to 77 months compared with no specific treatment (very low certainty).
1 finding from 1 review
Adverse events: thromboses · minimal change disease in adults with nephrotic syndrome
It is very uncertain whether intravenous ± oral steroids changes adverse events: thromboses compared with oral steroids alone (very low certainty).
1 finding from 1 review
Gastrointestinal bleeding · minimal change disease in adults with nephrotic syndrome
It is very uncertain whether intravenous ± oral steroids changes adverse events: gastrointestinal bleeding compared with oral steroids alone (very low certainty).
1 finding from 1 review
Complete remission · minimal change disease in adults with nephrotic syndrome
Calcineurin inhibitors ± oral steroids showed no clear difference in complete remission Time frame: 2 to 6 months compared with oral steroids alone (moderate certainty).
1 finding from 1 review
Complete or partial remission · minimal change disease in adults with nephrotic syndrome
Calcineurin inhibitors ± oral steroids showed no clear difference in complete or partial remission time frame: 3 to 6 months compared with oral steroids alone (moderate certainty).
1 finding from 1 review
Relapse · minimal change disease in adults with nephrotic syndrome
Calcineurin inhibitors ± oral steroids showed no clear difference in relapse Time frame: 6 to 12 months compared with oral steroids alone (moderate certainty).
1 finding from 1 review