Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,756 questions · 13,493 findings · 1,305 reviews · Headline outcomes only

No studies found 2,594 · 19.2%GRADE not reported 728 · 5.4%Very low 2,868 · 21.3%Low 3,777 · 28%Moderate 2,620 · 19.4%High 906 · 6.7%

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Hypoxia‐inducible factor (HIF) stabilisers vs placebo

Proportion reaching target haemoglobin Median · people with CKD (including HD and PD)

Hypoxia‐inducible factor (HIF) stabilisers probably leads to higher proportion reaching target haemoglobin Median compared with placebo (moderate certainty).

1 finding from 1 review

Memantine vs placebo

Adverse effects sufficient to stop treatment · Children aged 6 to 18 years with ASD

Memantine showed no clear difference in adverse effects Assessed by the study authors as those that were… compared with placebo (low certainty).

1 finding from 1 review