Findings

What do systematic reviews say?

2,890 questions · 3,917 findings · 272 reviews · All outcomes

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No studies found 429 · 11%GRADE not reported 2,657 · 67.8%Very low 512 · 13.1%Low 219 · 5.6%Moderate 80 · 2%High 20 · 0.5%

Primary school-based behavioural intervention (both oral hygiene and dietary components) vs No treatment (or delayed treatment)

Behavioural outcomes (reported and/or other measures, e.g. data tracking toothbrushes and collecting food wrappers) · Children aged 4 to 12 years attending primary school

The review found no eligible studies for this question.

1 finding from 1 review

Primary school‐based behavioural interventions for preventing caries 2013 · Cochrane All outcomes
No other behavioural outcomes (e.g. objective toothbrush tracking or food-wrapper collection) were measured by the four included studies.
0 studies
No studies found

Fluoride varnish vs placebo or no treatment

Proportion of children developing new caries (permanent) · Children and adolescents aged 16 years or less

Fluoride varnish showed no clear difference in proportion of children developing one or more new caries (permanent… compared with placebo or no treatment; GRADE not reported.

1 finding from 1 review

Fluoride varnishes for preventing dental caries in children and adolescents 2013 · Cochrane All outcomes
At least 1 year
RR 0.75 [0.53, 1.05]
5 studies · 3253 participants
GRADE not reported

One prophylactic antibiotic vs A different prophylactic antibiotic

Outcome not reported · Adults undergoing dental implant placement

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for replacing missing teeth: antibiotics at dental implant placement to prevent complications 2013 · Cochrane All outcomes
At least 3 months (planned)
no estimate extracted
0 studies
No studies found

Resin-based fissure sealant vs No comparator

Association between loss of complete retention risk and caries occurrence risk · Patients with fissure-sealed permanent molar teeth

Loss of complete sealant retention was directly associated with caries occurrence for resin-based sealants in the main analysis (regression slope 0.89, 95% CI 0.56 to 1.23; ungraded).

2 findings from 1 review

Validity of sealant retention as surrogate for caries prevention--a systematic review. 2013 All outcomes
At least 24 months · Main analysis
Regression slope (ln caries risk on ln retention-loss risk) 0.89 [0.56, 1.23]
54 studies · 17377 participants
GRADE not reported
Validity of sealant retention as surrogate for caries prevention--a systematic review. 2013 All outcomes
Longest follow-up per trial · Sensitivity analysis
Regression slope (ln caries risk on ln retention-loss risk) 0.53 [-0.27, 1.32]
14 studies · 3154 participants
GRADE not reported

Visual screening (oral visual inspection) by trained health workers vs No screening

Test performance (sensitivity and specificity) · Apparently healthy adults aged 35 years or older (general population), living in 13 clusters in rural areas of Trivandrum city, Kerala,…

1 finding from 1 review

Screening programmes for the early detection and prevention of oral cancer 2013 · Cochrane All outcomes
15-year follow-up
Across the four cycles (15 years), the reported sensitivity of the visual examination in detecting oral cancer was 67.4% (188/279). No information on the specificity or the positive predictive value of the programme…
1 study
GRADE not reported

Interdental brushing plus toothbrushing vs Flossing plus toothbrushing

Quality of life · Adults, 16 years and older (dentate)

The review found no eligible studies for this question.

1 finding from 1 review

Interdental brushing for the prevention and control of periodontal diseases and dental caries in adults 2013 · Cochrane All outcomes
Not estimable. No included study assessed quality of life as an outcome. (See comment)
0 studies
No studies found

Intervention not reported

Caries occurrence on sealed teeth

The intervention led to higher caries occurrence on sealed teeth; GRADE not reported.

1 finding from 1 review

The modified Ottawa method to establish the update need of a systematic review: glass-ionomer versus resin sealants… 2013 All outcomes
24 months, original datasets only (permanent teeth)
RR 2.10 [1.23, 3.58]
4 studies
GRADE not reported

Primary school-based behavioural intervention (both oral hygiene and dietary components) vs No treatment (or delayed treatment)

Adverse events · Children aged 4 to 12 years attending primary school

The review found no eligible studies for this question.

1 finding from 1 review

Primary school‐based behavioural interventions for preventing caries 2013 · Cochrane All outcomes
No study reported any adverse events.
0 studies
No studies found

Prophylactic systemic antibiotics (amoxicillin) vs placebo or no antibiotic

Prosthesis failure · Adults undergoing dental implant placement

Prophylactic systemic antibiotics (amoxicillin) showed no clear difference in prosthesis failure compared with no antibiotics or placebo; GRADE not reported.

1 finding from 1 review

Interventions for replacing missing teeth: antibiotics at dental implant placement to prevent complications 2013 · Cochrane All outcomes
3 to 5 months
RR 0.44 [0.19, 1.00]
5 studies · 1107 participants
GRADE not reported

Toluidine blue (visual staining) vs No screening

Outcome not reported · Planned population: general population or high-risk / opportunistic screening groups (no eligible study)

The review found no eligible studies for this question.

1 finding from 1 review

Screening programmes for the early detection and prevention of oral cancer 2013 · Cochrane All outcomes
There was no evidence to support the use of adjunctive technologies like toluidine blue, brush biopsy or fluorescence imaging as a screening tool to reduce oral cancer mortality; no eligible randomised controlled trial…
0 studies
No studies found

Resin composite restorations containing antibacterial agents vs Non-antibacterial containing composite restorations

Postoperative sensitivity, marginal adaptation, anatomic form and other clinical outcomes (USPHS restoration quality; includes tooth vitality and pulpitis) · Adults and adolescents in any age group with restorations in the permanent dentition and children with restorations in the primary dentition

The review found no eligible studies for this question.

1 finding from 1 review

Antibacterial agents in composite restorations for the prevention of dental caries 2013 · Cochrane All outcomes
No studies were included in this review, as we were unable to find any trials directly comparing antibacterial containing composites to other active interventions or controls.
0 studies
No studies found

Prophylactic systemic antibiotics (amoxicillin) vs placebo or no antibiotic

Postoperative infection · Adults undergoing dental implant placement

Prophylactic systemic antibiotics (amoxicillin) showed no clear difference in postoperative infection compared with no antibiotics or placebo; GRADE not reported.

1 finding from 1 review

Interventions for replacing missing teeth: antibiotics at dental implant placement to prevent complications 2013 · Cochrane All outcomes
3 to 5 months
RR 0.69 [0.36, 1.35]
6 studies · 1162 participants
GRADE not reported

Primary school-based behavioural intervention (both oral hygiene and dietary components) vs No treatment (or delayed treatment)

Caries increment, tooth index D(M)FT · Children aged 4 to 12 years attending primary school

1 finding from 1 review

Primary school‐based behavioural interventions for preventing caries 2013 · Cochrane All outcomes
2 years
PF 0.49
1 study
GRADE not reported

Intervention not reported

Risk of caries occurrence

1 finding from 1 review

Validity of sealant retention as surrogate for caries prevention--a systematic review. 2013 All outcomes
Main analysis; resin-based (Mat 1)
Mean risk (proportion of sealed teeth) 0.12 (SD 0.14)
54 studies
GRADE not reported

Primary school-based behavioural intervention (both oral hygiene and dietary components) vs No treatment (or delayed treatment)

Frequency of cariogenic food and drink consumption · Children aged 4 to 12 years attending primary school

1 finding from 1 review

Primary school‐based behavioural interventions for preventing caries 2013 · Cochrane All outcomes
Worthington 2001: few children had problems identifying foods containing sugar; only 15% of intervention and 19% of control participants reported routinely consuming sugary snacks on arriving home from school; snacking…
1 study
GRADE not reported

Brush biopsy (oral cytology) vs No screening

Outcome not reported · Planned population: general population or high-risk / opportunistic screening groups (no eligible study)

The review found no eligible studies for this question.

1 finding from 1 review

Screening programmes for the early detection and prevention of oral cancer 2013 · Cochrane All outcomes
There was no evidence to support the use of adjunctive technologies like toluidine blue, brush biopsy or fluorescence imaging as a screening tool to reduce oral cancer mortality; no eligible randomised controlled trial…
0 studies
No studies found

Primary school-based behavioural intervention (both oral hygiene and dietary components) vs No treatment (or delayed treatment)

Frequency of toothbrushing · Children aged 4 to 12 years attending primary school

1 finding from 1 review

Primary school‐based behavioural interventions for preventing caries 2013 · Cochrane All outcomes
Worthington 2001 reported children's brushing frequency: almost all children (99%) at baseline reported twice daily brushing, and this level was maintained across all groups throughout the intervention (in baseline…
1 study
GRADE not reported

Intervention not reported

Risk of caries occurrence

1 finding from 1 review

Validity of sealant retention as surrogate for caries prevention--a systematic review. 2013 All outcomes
Main analysis; GIC-based (Mat 2)
Mean risk (proportion of sealed teeth) 0.12 (SD 0.08)
22 studies
GRADE not reported

Interdental brushing plus toothbrushing vs Toothbrushing alone

Periodontitis (clinical attachment loss) · Adults, 16 years and older (dentate)

The review found no eligible studies for this question.

1 finding from 1 review

Interdental brushing for the prevention and control of periodontal diseases and dental caries in adults 2013 · Cochrane All outcomes
Not estimable. No included study assessed periodontitis as an outcome. (See comment)
0 studies
No studies found

Fluorescence imaging / light-based techniques vs No screening

Outcome not reported · Planned population: general population or high-risk / opportunistic screening groups (no eligible study)

The review found no eligible studies for this question.

1 finding from 1 review

Screening programmes for the early detection and prevention of oral cancer 2013 · Cochrane All outcomes
There was no evidence to support the use of adjunctive technologies like toluidine blue, brush biopsy or fluorescence imaging as a screening tool to reduce oral cancer mortality; no eligible randomised controlled trial…
0 studies
No studies found