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Probiotics showed no clear difference in recurrent episodes of HAEC compared with placebo (low certainty).
Antibiotics showed no clear difference in failure to induce clinical remission at end of study compared with placebo (high certainty).
Antibiotics showed no clear difference in failure to induce clinical response at end of study compared with placebo (low certainty).
Antibiotics showed no clear difference in serious adverse events compared with placebo (low certainty).
Antibiotics showed no clear difference in withdrawals due to adverse events compared with placebo (low certainty).
It is very uncertain whether antibiotics plus probiotics changes failure to induce clinical remission at end of study compared with placebo or no intervention (very low certainty).
The review found no eligible studies for this question.
It is very uncertain whether antibiotics plus probiotics changes serious adverse events compared with placebo or no intervention (very low certainty).
It is very uncertain whether antibiotics plus probiotics changes withdrawals due to adverse events compared with placebo or no intervention (very low certainty).
Certolizumab pegol probably leads to lower failure to maintain clinical remission at week 26(1 RCT, 428… compared with placebo (moderate certainty).
Certolizumab pegol probably leads to lower failure to maintain clinical response at week 26(1 RCT, 428… compared with placebo (moderate certainty).
Certolizumab pegol showed no clear difference in serious adverse events during remission maintenance treatment(1 RCT,… compared with placebo (low certainty).
It is very uncertain whether hypoxia‐inducible factor (HIF) stabilisers changes cardiovascular death Median compared with placebo (very low certainty).
The review found no eligible studies for this question.
The review found no eligible studies for this question.
It is very uncertain whether hypoxia‐inducible factor (HIF) stabilisers changes nonfatal myocardial infarction Median compared with placebo (very low certainty).
Hypoxia‐inducible factor (HIF) stabilisers probably leads to lower proportion of patients requiring blood transfusion Median compared with placebo (moderate certainty).