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Oral showed no clear difference in overall survival compared with intravenous fluoropyrimidines (high certainty).
Oral may leads to higher grade ≥ 3 diarrhoea compared with intravenous fluoropyrimidines (low certainty).
Oral probably leads to higher grade ≥ 3 hand foot syndrome compared with intravenous fluoropyrimidines (moderate certainty).
HALOPERIDOL probably leads to higher tranquillisation or asleep compared with COMBINATIONS: d. HALOPERIDOL + PROMETHAZINE (moderate certainty).
It is very uncertain whether HALOPERIDOL changes repeated need for tranquillisation compared with COMBINATIONS: d. HALOPERIDOL + PROMETHAZINE (very low certainty).
HALOPERIDOL showed no clear difference in specific behaviours ‐ aggression compared with COMBINATIONS: d. HALOPERIDOL + PROMETHAZINE (moderate certainty).
HALOPERIDOL showed no clear difference in global outcomes compared with COMBINATIONS: d. HALOPERIDOL + PROMETHAZINE (moderate certainty).
HALOPERIDOL may leads to higher adverse effects: specific ‐ acute dystonia compared with COMBINATIONS: d. HALOPERIDOL + PROMETHAZINE (low certainty).
HALOPERIDOL showed no clear difference in adverse effects: specific ‐ seizure compared with COMBINATIONS: d. HALOPERIDOL + PROMETHAZINE (low certainty).
The review found no eligible studies for this question.
Chemoradiotherapy showed no clear difference in overall survival compared with chemoradiotherapy plus surgery (high certainty).
Chemoradiotherapy probably leads to lower freedom from locoregional relapse compared with chemoradiotherapy plus surgery (moderate certainty).
Chemoradiotherapy may leads to higher treatment‐related mortality compared with chemoradiotherapy plus surgery (low certainty).
Chemoradiotherapy may leads to lower use of salvage procedures for dysphagia compared with chemoradiotherapy plus surgery (low certainty).
Summary of findings table ‐ Transcutaneous bilirubin (TcB) screening probably leads to lower readmission for phototherapy for hyperbilirubinemia compared with visual assessment (moderate certainty).
Summary of findings table ‐ Transcutaneous bilirubin (TcB) screening showed no clear difference in exchange transfusion compared with visual assessment (low certainty).
Summary of findings table ‐ Transcutaneous bilirubin (TcB) screening probably leads to higher phototherapy before hospital discharge compared with visual assessment (moderate certainty).
Summary of findings table ‐ Transcutaneous bilirubin (TcB) screening showed no clear difference in acute bilirubin encephalopathy compared with visual assessment (low certainty).