Type 2 diabetes (prevalent) · Adults (general population)
Meta-analysis of observational studies (higher vs lower 25(OH)D) for Type 2 diabetes (prevalent): OR 0.45 (95% CI 0.25 to 0.82), statistically significant. Umbrella review outcome-level evidence grade: No conclusion.
1 finding from 1 review
All cause mortality · Adults (general population)
Meta-analysis of observational studies (higher vs lower 25(OH)D) for All cause mortality: HR 0.72 (95% CI 0.66 to 0.78), statistically significant. Umbrella review outcome-level evidence grade: No conclusion.
1 finding from 1 review
Rectal cancer · Adults (general population)
Meta-analysis of observational studies (higher vs lower 25(OH)D) for Rectal cancer: OR 0.50 (95% CI 0.29 to 0.88), statistically significant. Umbrella review outcome-level evidence grade: No conclusion.
1 finding from 1 review
Relative DOR by setting (FC, advanced, occlusal permanent) · Permanent teeth, occlusal surfaces, with suspected caries lesions
No significant setting difference for FC (RDOR 2.96, 0.36 to 24.45).
2 findings from 1 review
Tooth decay-free children · Alaska children aged 5 to 18 years
The robust prevention PDHA model was projected to yield more than 50% tooth decay-free children versus 8% with other PDHA models, without a GRADE rating.
1 finding from 1 review
More advanced caries lesion detection · Primary teeth with approximal surfaces
Pooled specificity was reported, but the numerical estimate is not stated in the supplied text or attached figures; I²=89%; no GRADE rating was reported.
2 findings from 1 review
Initial caries lesion detection · Primary teeth with occlusal surfaces
Pooled sensitivity was reported, but the numerical estimate is not stated in the supplied text or attached figures; I²=0%; no GRADE rating was reported.
2 findings from 1 review
Sensitivity 0.482 [0.433, 0.531]
2 studies
GRADE not reported
Specificity 0.815 [0.713, 0.892]
2 studies
GRADE not reported
Diagnostic accuracy (pooled sensitivity, specificity, diagnostic odds ratio, summary-ROC AUC) · Permanent teeth, occlusal surfaces, with suspected caries lesions
Pen-type laser fluorescence on occlusal surfaces of permanent teeth (more advanced-lesion threshold): pooled DOR for LFpen lower than for LF and FC; heterogeneity I2=73%. Diagnostic accuracy was not formally graded (GRADE not used).
2 findings from 1 review
Fluorescence-based methods for detecting caries lesions: systematic review, meta-analysis and sources of heterogeneity. 2013 All outcomesMore advanced (dentine/cavitated) caries lesions threshold · Laboratory (in vitro) and clinical (in vivo)
Pooled sensitivity, specificity, DOR, PLR, NLR and summary-ROC AUC reported qualitatively (Figure 6); pooled DOR for LFpen lower than for LF and FC. Heterogeneity I2=73%. Numeric pooled values not available in the…
Studies not reported
GRADE not reported
Pooled sensitivity, specificity, DOR, PLR, NLR and summary-ROC AUC reported qualitatively (Figure 6); accuracy similar among LF, LFpen and FC. Heterogeneity I2=54%. Numeric pooled values not available in the provided…
Studies not reported
GRADE not reported
Baby bottle tooth decay prevalence · Alaska Native and American Indian Head Start children
High-intensity community education was associated with a 33% reduction in BBTD prevalence, without a GRADE rating.
3 findings from 1 review
Percent reduction in BBTD prevalence 33
1 study
GRADE not reported
Percent reduction in BBTD prevalence 18
1 study
GRADE not reported
Percent reduction in BBTD prevalence 27
1 study
GRADE not reported
More advanced caries lesion detection · Permanent teeth with occlusal surfaces
Pooled sensitivity was reported, but the numerical estimate is not stated in the supplied text or attached figures; I²=73%; no GRADE rating was reported.
2 findings from 1 review
Relative DOR by reference standard (LF, advanced, occlusal permanent) · Permanent teeth, occlusal surfaces, with suspected caries lesions
No significant difference vs histological for LF at the advanced threshold (RDOR 0.62, 0.15 to 2.46).
2 findings from 1 review
Projected Significant Caries (SiC) index · Alaska Native children (below age 18)
A simulation projected a 50% drop in the Significant Caries index for children (12.3 to 6.1) under the PDHA model (certainty not graded).
2 findings from 1 review
Projected proportion of caries-free children (5-18 years) · Alaska Native children (below age 18)
A simulation projected 0% of children aged 5-18 would be caries-free under the baseline scenario (certainty not graded).
3 findings from 1 review
Intervention not reported
Caries occurrence on sealed teeth
The intervention showed no clear difference in caries occurrence on sealed teeth; GRADE not reported.
1 finding from 1 review
RR 2.61 [0.61, 11.14]
2 studies
GRADE not reported
Initial caries lesion detection · Permanent teeth with occlusal surfaces
Pooled specificity was reported, but the numerical estimate is not stated in the supplied text or attached figures; I²=54%; no GRADE rating was reported.
2 findings from 1 review
Specificity 0.818 [0.751, 0.873]
9 studies
GRADE not reported
Sensitivity 0.749 [0.715, 0.781]
9 studies
GRADE not reported
Caries occurrence on sealed teeth · Sealed permanent teeth
Glass-ionomer and resin-based fissure sealants showed no statistically significant difference in caries occurrence on sealed permanent teeth at 12 months (no GRADE rating).
3 findings from 1 review
RR 1.66 [0.75, 3.68]
5 studies · 1952 participants
GRADE not reported
RR 2.04 [0.62, 6.70]
6 studies · 1944 participants
GRADE not reported
RR 1.51 [1.00, 2.28]
8 studies · 2810 participants
GRADE not reported
More advanced caries lesion detection · Permanent teeth with approximal surfaces
Pooled specificity was reported, but the numerical estimate is not stated in the supplied text or attached figures; I²=84%; no GRADE rating was reported.
2 findings from 1 review
Diagnostic accuracy (pooled sensitivity, specificity, diagnostic odds ratio, summary-ROC AUC) · Permanent teeth, occlusal surfaces, with suspected caries lesions
Laser fluorescence on occlusal surfaces of permanent teeth (initial-lesion threshold): accuracy (sensitivity, specificity, DOR, PLR, NLR, sROC AUC) similar among LF, LFpen and FC; heterogeneity I2=65%. Diagnostic accuracy was not formally graded (GRADE not used).
2 findings from 1 review
Pooled sensitivity, specificity, DOR, PLR, NLR and summary-ROC AUC reported qualitatively (Figure 6); accuracy (sensitivity, specificity, DOR, PLR, NLR, sROC AUC) similar among LF, LFpen and FC. Heterogeneity I2=65%.…
Studies not reported
GRADE not reported
Fluorescence-based methods for detecting caries lesions: systematic review, meta-analysis and sources of heterogeneity. 2013 All outcomesMore advanced (dentine/cavitated) caries lesions threshold · Laboratory (in vitro) and clinical (in vivo)
Pooled sensitivity, specificity, DOR, PLR, NLR and summary-ROC AUC reported qualitatively (Figure 6); pooled DOR higher for LF (and FC) than for LFpen. Heterogeneity I2=77%. Numeric pooled values not available in the…
Studies not reported
GRADE not reported
Initial caries lesion detection · Permanent teeth with approximal surfaces
Pooled specificity was reported, but the numerical estimate is not stated in the supplied text or attached figures; I²=93%; no GRADE rating was reported.
2 findings from 1 review
Technical performance / deficient restorations (DHATs vs dentists) · Alaska Native dental patients (children aged 6-17 and adults) and their caregivers
DHATs had a lower amalgam restoration deficiency rate than dentists (12% vs 22%; certainty not graded).
3 findings from 1 review