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Ciprofloxacin showed no clear difference in frequency of infective pulmonary exacerbations: proportion of… compared with placebo added to cycled and culture‐based inhaled tobramycin (TNS)… (moderate certainty).
Ciprofloxacin showed no clear difference in isolation of other micro‐organisms from the respiratory tract:… compared with placebo added to cycled and culture‐based inhaled tobramycin (TNS)… (moderate certainty).
Ciprofloxacin showed no clear difference in adverse effects of antibiotics: proportion of participants with one… compared with placebo added to cycled and culture‐based inhaled tobramycin (TNS)… (moderate certainty).
Cytisine may leads to higher smoking abstinence at longest compared with nicotine replacement therapy (low certainty).
It is very uncertain whether cytisine changes SAEs compared with nicotine replacement therapy (very low certainty).
The review found no eligible studies for this question.
The review found no eligible studies for this question.
Varenicline leads to higher smoking abstinence at longest compared with nicotine replacement therapy monotherapy (high certainty).
Varenicline may leads to lower SAEs compared with nicotine replacement therapy monotherapy (low certainty).
Varenicline showed no clear difference in smoking abstinence at longest compared with combination nicotine replacement therapy (low certainty).
Varenicline showed no clear difference in SAEs compared with combination nicotine replacement therapy (low certainty).
Varenicline showed no clear difference in neuropsychiatric SAEs compared with combination nicotine replacement therapy (low certainty).
Varenicline showed no clear difference in cardiac SAEs compared with combination nicotine replacement therapy (low certainty).
The review found no eligible studies for this question.
It is very uncertain whether summary of findings 2: PLD alone changes overall severe adverse events (grade > 3) compared with other conventional chemotherapy (very low certainty).
It is very uncertain whether summary of findings 2: PLD alone changes anaemia (grade ≥ 3) compared with other conventional chemotherapy (very low certainty).
It is very uncertain whether summary of findings 2: PLD alone changes hand‐foot syndrome (grade ≥ 3) compared with other conventional chemotherapy (very low certainty).