Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,756 questions · 13,493 findings · 1,305 reviews · Headline outcomes only

No studies found 2,594 · 19.2%GRADE not reported 728 · 5.4%Very low 2,868 · 21.3%Low 3,777 · 28%Moderate 2,620 · 19.4%High 906 · 6.7%

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Tocilizumab every 4 weeks vs placebo

Proportion of participants who did not need escape therapy (as defined by study investigators) · adults aged over 50 years with giant cell arteritis

The review found no eligible studies for this question.

1 finding from 1 review

Tocilizumab every 4 weeks vs placebo

Mean change in quality of life at ≥ 12 months using the 36‐Item Short Form Health Survey mental component score (SF‐36 MCS) · adults aged over 50 years with giant cell arteritis

The review found no eligible studies for this question.

1 finding from 1 review

Tocilizumab every 4 weeks vs placebo

Mean change in VAS (higher scores suggest greater disease activity and worse quality of life) at ≥ 12 months · adults aged over 50 years with giant cell arteritis

The review found no eligible studies for this question.

1 finding from 1 review

Intravenous magnesium sulfate + standard care vs placebo + standard care

Proportion of people with hospital admissions (from the emergency room) · acute exacerbations of chronic obstructive pulmonary disease

Intravenous magnesium sulfate + standard care may leads to lower proportion of people with hospital admissions (from the emergency… compared with placebo + standard care (low certainty).

1 finding from 1 review

Nebulised magnesium sulfate + standard care vs placebo + standard care

Proportion of people requiring ventilatory support (NIV or assisted ventilation) · acute exacerbations of chronic obstructive pulmonary disease

It is very uncertain whether nebulised magnesium sulfate + standard care changes proportion of people requiring ventilatory support (NIV or assisted… compared with placebo + standard care (very low certainty).

1 finding from 1 review

Intravenous magnesium sulfate + standard care vs placebo + standard care

Proportion of people requiring non‐invasive ventilation · acute exacerbations of chronic obstructive pulmonary disease

It is very uncertain whether intravenous magnesium sulfate + standard care changes proportion of people requiring non‐invasive ventilation compared with placebo + standard care (very low certainty).

1 finding from 1 review

Nebulised magnesium sulfate + standard care vs placebo + standard care

Proportion of people with hospital admissions (from the emergency room) · acute exacerbations of chronic obstructive pulmonary disease

It is very uncertain whether nebulised magnesium sulfate + standard care changes proportion of people with hospital admissions (from the emergency… compared with placebo + standard care (very low certainty).

1 finding from 1 review

Nebulised magnesium sulfate + standard care vs placebo + standard care

Incidence of admissions to the ICU · acute exacerbations of chronic obstructive pulmonary disease

It is very uncertain whether nebulised magnesium sulfate + standard care changes proportion of people requiring ICU admission compared with placebo + standard care (very low certainty).

1 finding from 1 review